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Iron Reshapes the Gut Microbiome and Host Metabolism
Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic di...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Lipidology and Atherosclerosis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159756/ https://www.ncbi.nlm.nih.gov/pubmed/34095010 http://dx.doi.org/10.12997/jla.2021.10.2.160 |
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author | Botta, Amy Barra, Nicole G. Lam, Nhat Hung Chow, Samantha Pantopoulos, Kostas Schertzer, Jonathan D. Sweeney, Gary |
author_facet | Botta, Amy Barra, Nicole G. Lam, Nhat Hung Chow, Samantha Pantopoulos, Kostas Schertzer, Jonathan D. Sweeney, Gary |
author_sort | Botta, Amy |
collection | PubMed |
description | Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Although iron is well characterized as a frequent traveling companion of metabolic disease, the role of iron is underappreciated because the mechanisms of iron's influence on host metabolism are poorly characterized. Both iron deficiency and excessive amounts leading to iron overload can have detrimental effects on cardiometabolic health. Optimal iron homeostasis is critical for regulation of host immunity and metabolism in addition to regulation of commensal and pathogenic enteric bacteria. In this article we review evidence to support the notion that altering composition of the gut microbiome may be an important route via which iron impacts cardiometabolic health. We discuss reshaping of the microbiome by iron, the physiological significance and the potential for therapeutic interventions. |
format | Online Article Text |
id | pubmed-8159756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Lipidology and Atherosclerosis |
record_format | MEDLINE/PubMed |
spelling | pubmed-81597562021-06-04 Iron Reshapes the Gut Microbiome and Host Metabolism Botta, Amy Barra, Nicole G. Lam, Nhat Hung Chow, Samantha Pantopoulos, Kostas Schertzer, Jonathan D. Sweeney, Gary J Lipid Atheroscler Review Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Although iron is well characterized as a frequent traveling companion of metabolic disease, the role of iron is underappreciated because the mechanisms of iron's influence on host metabolism are poorly characterized. Both iron deficiency and excessive amounts leading to iron overload can have detrimental effects on cardiometabolic health. Optimal iron homeostasis is critical for regulation of host immunity and metabolism in addition to regulation of commensal and pathogenic enteric bacteria. In this article we review evidence to support the notion that altering composition of the gut microbiome may be an important route via which iron impacts cardiometabolic health. We discuss reshaping of the microbiome by iron, the physiological significance and the potential for therapeutic interventions. Korean Society of Lipidology and Atherosclerosis 2021-05 2021-03-10 /pmc/articles/PMC8159756/ /pubmed/34095010 http://dx.doi.org/10.12997/jla.2021.10.2.160 Text en Copyright © 2021 The Korean Society of Lipid and Atherosclerosis. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Botta, Amy Barra, Nicole G. Lam, Nhat Hung Chow, Samantha Pantopoulos, Kostas Schertzer, Jonathan D. Sweeney, Gary Iron Reshapes the Gut Microbiome and Host Metabolism |
title | Iron Reshapes the Gut Microbiome and Host Metabolism |
title_full | Iron Reshapes the Gut Microbiome and Host Metabolism |
title_fullStr | Iron Reshapes the Gut Microbiome and Host Metabolism |
title_full_unstemmed | Iron Reshapes the Gut Microbiome and Host Metabolism |
title_short | Iron Reshapes the Gut Microbiome and Host Metabolism |
title_sort | iron reshapes the gut microbiome and host metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159756/ https://www.ncbi.nlm.nih.gov/pubmed/34095010 http://dx.doi.org/10.12997/jla.2021.10.2.160 |
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