Mendelian randomisation for mediation analysis: current methods and challenges for implementation

Mediation analysis seeks to explain the pathway(s) through which an exposure affects an outcome. Traditional, non-instrumental variable methods for mediation analysis experience a number of methodological difficulties, including bias due to confounding between an exposure, mediator and outcome and m...

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Detalles Bibliográficos
Autores principales: Carter, Alice R., Sanderson, Eleanor, Hammerton, Gemma, Richmond, Rebecca C., Davey Smith, George, Heron, Jon, Taylor, Amy E., Davies, Neil M., Howe, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Essay
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159796/
https://www.ncbi.nlm.nih.gov/pubmed/33961203
http://dx.doi.org/10.1007/s10654-021-00757-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159796/
https://www.ncbi.nlm.nih.gov/pubmed/33961203
http://dx.doi.org/10.1007/s10654-021-00757-1

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