Characteristic metabolites of Hypericum plants: their chemical structures and biological activities

Plants belonging to the genus Hypericum (Hypericaceae) are recognized as an abundant source of natural products with interesting chemical structures and intriguing biological activities. In the course of our continuing study on constituents of Hypericum plants, aiming at searching natural product-ba...

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Autores principales: Tanaka, Naonobu, Kashiwada, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159811/
https://www.ncbi.nlm.nih.gov/pubmed/33555487
http://dx.doi.org/10.1007/s11418-021-01489-y
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author Tanaka, Naonobu
Kashiwada, Yoshiki
author_facet Tanaka, Naonobu
Kashiwada, Yoshiki
author_sort Tanaka, Naonobu
collection PubMed
description Plants belonging to the genus Hypericum (Hypericaceae) are recognized as an abundant source of natural products with interesting chemical structures and intriguing biological activities. In the course of our continuing study on constituents of Hypericum plants, aiming at searching natural product-based lead compounds for therapeutic agents, we have isolated more than 100 new characteristic metabolites classified as prenylated acylphloroglucinols, meroterpenes, ketides, dibenzo-1,4-dioxane derivatives, and xanthones including prenylated xanthones, phenylxanthones, and xanthonolignoids from 11 Hypericum plants and one Triadenum plant collected in Japan, China, and Uzbekistan or cultivated in Japan. This review summarizes their chemical structures and biological activities.
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spelling pubmed-81598112021-06-01 Characteristic metabolites of Hypericum plants: their chemical structures and biological activities Tanaka, Naonobu Kashiwada, Yoshiki J Nat Med Review Plants belonging to the genus Hypericum (Hypericaceae) are recognized as an abundant source of natural products with interesting chemical structures and intriguing biological activities. In the course of our continuing study on constituents of Hypericum plants, aiming at searching natural product-based lead compounds for therapeutic agents, we have isolated more than 100 new characteristic metabolites classified as prenylated acylphloroglucinols, meroterpenes, ketides, dibenzo-1,4-dioxane derivatives, and xanthones including prenylated xanthones, phenylxanthones, and xanthonolignoids from 11 Hypericum plants and one Triadenum plant collected in Japan, China, and Uzbekistan or cultivated in Japan. This review summarizes their chemical structures and biological activities. Springer Singapore 2021-02-08 2021 /pmc/articles/PMC8159811/ /pubmed/33555487 http://dx.doi.org/10.1007/s11418-021-01489-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Tanaka, Naonobu
Kashiwada, Yoshiki
Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title_full Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title_fullStr Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title_full_unstemmed Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title_short Characteristic metabolites of Hypericum plants: their chemical structures and biological activities
title_sort characteristic metabolites of hypericum plants: their chemical structures and biological activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159811/
https://www.ncbi.nlm.nih.gov/pubmed/33555487
http://dx.doi.org/10.1007/s11418-021-01489-y
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