Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment, and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by well-characterized biosynthetic enzymes; however the regulation of these enzym...

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Detalles Bibliográficos
Autores principales: Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W.T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L.S.M., Lewis, Nathan E., Esko, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159865/
https://www.ncbi.nlm.nih.gov/pubmed/33846619
http://dx.doi.org/10.1038/s41589-021-00776-9

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