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REPRESSION OF CTSG, ELANE, AND PRTN3-MEDIATED HISTONE H3 PROTEOLYTIC CLEAVAGE PROMOTES MONOCYTE-TO-MACROPHAGE DIFFERENTIATION

Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report repression of controlled histone H3 amino-terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark in human peripheral blood monocytes is catalyzed by neut...

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Detalles Bibliográficos
Autores principales:	Cheung, Peggie, Schaffert, Steven, Chang, Sarah E., Dvorak, Mai, Donato, Michele, Macaubas, Claudia, Foecke, Mariko H., Li, Tie-Mei, Zhang, Lichao, Coan, John P., Schulert, Grant S., Grom, Alexei A., Henderson, Lauren A., Nigrovic, Peter A., Elias, Joshua E., Gozani, Or, Mellins, Elizabeth D., Khatri, Purvesh, Utz, Paul J., Kuo, Alex J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159908/ https://www.ncbi.nlm.nih.gov/pubmed/34017121 http://dx.doi.org/10.1038/s41590-021-00928-y

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