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The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study

Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS II score,...

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Autores principales: Hu, Tianyang, Lv, Huajie, Jiang, Youfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159970/
https://www.ncbi.nlm.nih.gov/pubmed/34045645
http://dx.doi.org/10.1038/s41598-021-90806-2
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author Hu, Tianyang
Lv, Huajie
Jiang, Youfan
author_facet Hu, Tianyang
Lv, Huajie
Jiang, Youfan
author_sort Hu, Tianyang
collection PubMed
description Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS II score, SIRS score, SOFA score, and 30-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) intensive care unit (ICU) database. Receiver operating characteristic (ROC) curves and comparisons between the areas under the ROC curves (AUC) were conducted. Decision curve analysis (DCA) was performed to determine the net benefits between the four scoring systems and 30-day mortality of sepsis. For all cases in the cohort study, the AUC of LODS, SAPS II, SIRS, SOFA were 0.733, 0.787, 0.597, and 0.688, respectively. The differences between the scoring systems were statistically significant (all P-values < 0.0001), and stratified analyses (the elderly and non-elderly) also showed the superiority of SAPS II among the four systems. According to the DCA, the net benefit ranges in descending order were SAPS II, LODS, SOFA, and SIRS. For stratified analyses of the elderly or non-elderly groups, the results also showed that SAPS II had the most net benefit. Among the four commonly used scoring systems, the SAPS II score has the highest predictive value for 30-day mortality from sepsis, which is better than LODS, SIRS, and SOFA. The results of the DCA curves show that using the SAPS II score to predict the 30-day mortality of intensive care patients with sepsis to guide clinical applications may obtain the highest net benefit.
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spelling pubmed-81599702021-05-28 The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study Hu, Tianyang Lv, Huajie Jiang, Youfan Sci Rep Article Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS II score, SIRS score, SOFA score, and 30-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) intensive care unit (ICU) database. Receiver operating characteristic (ROC) curves and comparisons between the areas under the ROC curves (AUC) were conducted. Decision curve analysis (DCA) was performed to determine the net benefits between the four scoring systems and 30-day mortality of sepsis. For all cases in the cohort study, the AUC of LODS, SAPS II, SIRS, SOFA were 0.733, 0.787, 0.597, and 0.688, respectively. The differences between the scoring systems were statistically significant (all P-values < 0.0001), and stratified analyses (the elderly and non-elderly) also showed the superiority of SAPS II among the four systems. According to the DCA, the net benefit ranges in descending order were SAPS II, LODS, SOFA, and SIRS. For stratified analyses of the elderly or non-elderly groups, the results also showed that SAPS II had the most net benefit. Among the four commonly used scoring systems, the SAPS II score has the highest predictive value for 30-day mortality from sepsis, which is better than LODS, SIRS, and SOFA. The results of the DCA curves show that using the SAPS II score to predict the 30-day mortality of intensive care patients with sepsis to guide clinical applications may obtain the highest net benefit. Nature Publishing Group UK 2021-05-27 /pmc/articles/PMC8159970/ /pubmed/34045645 http://dx.doi.org/10.1038/s41598-021-90806-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hu, Tianyang
Lv, Huajie
Jiang, Youfan
The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_full The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_fullStr The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_full_unstemmed The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_short The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_sort association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159970/
https://www.ncbi.nlm.nih.gov/pubmed/34045645
http://dx.doi.org/10.1038/s41598-021-90806-2
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