Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

N(6)-methyladenosine (m(6)A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and transcription, but the intrinsic mechanism remains unclear. Here, we report that YTHDC1 plays indispensable roles in the self-renewal and di...

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Detalles Bibliográficos
Autores principales: Chen, Chuan, Liu, Wenqiang, Guo, Jiayin, Liu, Yuanyuan, Liu, Xuelian, Liu, Jun, Dou, Xiaoyang, Le, Rongrong, Huang, Yixin, Li, Chong, Yang, Lingyue, Kou, Xiaochen, Zhao, Yanhong, Wu, You, Chen, Jiayu, Wang, Hong, Shen, Bin, Gao, Yawei, Gao, Shaorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160034/
https://www.ncbi.nlm.nih.gov/pubmed/33886094
http://dx.doi.org/10.1007/s13238-021-00837-8

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