Cargando…

The Last Chance Saloon

Accurate chromosome segregation requires the removal of all chromatin bridges, which link chromosomes before cell division. When chromatin bridges fail to be removed, cell cycle progression may halt, or cytokinesis failure and ensuing polyploidization may occur. Conversely, the inappropriate severin...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Ye, Zhang, Hongtao, Gartner, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160109/
https://www.ncbi.nlm.nih.gov/pubmed/34055803
http://dx.doi.org/10.3389/fcell.2021.671297
_version_ 1783700214547218432
author Hong, Ye
Zhang, Hongtao
Gartner, Anton
author_facet Hong, Ye
Zhang, Hongtao
Gartner, Anton
author_sort Hong, Ye
collection PubMed
description Accurate chromosome segregation requires the removal of all chromatin bridges, which link chromosomes before cell division. When chromatin bridges fail to be removed, cell cycle progression may halt, or cytokinesis failure and ensuing polyploidization may occur. Conversely, the inappropriate severing of chromatin bridges leads to chromosome fragmentation, excessive genome instability at breakpoints, micronucleus formation, and chromothripsis. In this mini-review, we first describe the origins of chromatin bridges, the toxic processing of chromatin bridges by mechanical force, and the TREX1 exonuclease. We then focus on the abscission checkpoint (NoCut) which can confer a transient delay in cytokinesis progression to facilitate bridge resolution. Finally, we describe a recently identified mechanism uncovered in C. elegans where the conserved midbody associated endonuclease LEM-3/ANKLE1 is able to resolve chromatin bridges generated by various perturbations of DNA metabolism at the final stage of cell division. We also discuss how LEM-3 dependent chromatin bridge resolution may be coordinated with abscission checkpoint (NoCut) to achieve an error-free cleavage, therefore acting as a “last chance saloon” to facilitate genome integrity and organismal survival.
format Online
Article
Text
id pubmed-8160109
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81601092021-05-29 The Last Chance Saloon Hong, Ye Zhang, Hongtao Gartner, Anton Front Cell Dev Biol Cell and Developmental Biology Accurate chromosome segregation requires the removal of all chromatin bridges, which link chromosomes before cell division. When chromatin bridges fail to be removed, cell cycle progression may halt, or cytokinesis failure and ensuing polyploidization may occur. Conversely, the inappropriate severing of chromatin bridges leads to chromosome fragmentation, excessive genome instability at breakpoints, micronucleus formation, and chromothripsis. In this mini-review, we first describe the origins of chromatin bridges, the toxic processing of chromatin bridges by mechanical force, and the TREX1 exonuclease. We then focus on the abscission checkpoint (NoCut) which can confer a transient delay in cytokinesis progression to facilitate bridge resolution. Finally, we describe a recently identified mechanism uncovered in C. elegans where the conserved midbody associated endonuclease LEM-3/ANKLE1 is able to resolve chromatin bridges generated by various perturbations of DNA metabolism at the final stage of cell division. We also discuss how LEM-3 dependent chromatin bridge resolution may be coordinated with abscission checkpoint (NoCut) to achieve an error-free cleavage, therefore acting as a “last chance saloon” to facilitate genome integrity and organismal survival. Frontiers Media S.A. 2021-05-14 /pmc/articles/PMC8160109/ /pubmed/34055803 http://dx.doi.org/10.3389/fcell.2021.671297 Text en Copyright © 2021 Hong, Zhang and Gartner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hong, Ye
Zhang, Hongtao
Gartner, Anton
The Last Chance Saloon
title The Last Chance Saloon
title_full The Last Chance Saloon
title_fullStr The Last Chance Saloon
title_full_unstemmed The Last Chance Saloon
title_short The Last Chance Saloon
title_sort last chance saloon
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160109/
https://www.ncbi.nlm.nih.gov/pubmed/34055803
http://dx.doi.org/10.3389/fcell.2021.671297
work_keys_str_mv AT hongye thelastchancesaloon
AT zhanghongtao thelastchancesaloon
AT gartneranton thelastchancesaloon
AT hongye lastchancesaloon
AT zhanghongtao lastchancesaloon
AT gartneranton lastchancesaloon