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Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies

Introduction: Hypertension is one of the major risk factors to human health and human studies on association between gut microbiota and hypertension or blood pressure have received increased attention. In the present study, we aim to evaluate gut microbiota dysbiosis in human hypertension using a me...

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Autores principales: Guo, Yang, Li, Xiaosu, Wang, Zhijian, Yu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160125/
https://www.ncbi.nlm.nih.gov/pubmed/34055933
http://dx.doi.org/10.3389/fcvm.2021.650227
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author Guo, Yang
Li, Xiaosu
Wang, Zhijian
Yu, Bo
author_facet Guo, Yang
Li, Xiaosu
Wang, Zhijian
Yu, Bo
author_sort Guo, Yang
collection PubMed
description Introduction: Hypertension is one of the major risk factors to human health and human studies on association between gut microbiota and hypertension or blood pressure have received increased attention. In the present study, we aim to evaluate gut microbiota dysbiosis in human hypertension using a method of systematic review. Methods: PubMed, EMBASE, and Web of Science databases were searched until March 2021 to identify eligible articles. Additional articles were also identified by searching specific authors in this field. Inclusion criteria were observational studies based on stool samples with hypertension group and control group. Newcastle-Ottawa quality assessment scale (NOS) was used to assess the quality of the included studies. PROSPERO registration number: CRD42020212219. Results: A total of 17 studies enrolling 9,085 participants were included. Fifteen of the enrolled studies showed good quality and two studies showed fair quality based on NOS. We found alpha diversity in hypertension decreased significantly and microbial structure can be separated compared with control groups. Gut microbiota of hypertension showed depletion of short chain fatty acids (SCFAs) producers and over-growth of some Proteobacteria and Bacteroidetes members. Up-regulation of lipopolysaccharide biosynthesis, phosphotransferase system, ABC transporters, etc. and down-regulation of some amino acid metabolism, etc. in hypertension were reported. Fecal SCFAs levels increased and plasma SCFAs levels decreased in hypertension. Stronger microbial interactions in hypertension were seen. Conclusion: In conclusion, gut microbiota dysbiosis was observed in hypertension, including decreased diversity, altered microbial structure, compositional change of taxa, alterations of microbial function, nutritional and immunological factors, and microbial interactions. Poor absorption and high excretion of SCFAs may play an important role in the pathogenesis of hypertension. These findings may provide insights into etiology study and new microbial-based therapies of hypertension. Systematic Review Registration: PROSPERO database, identifier CRD42020212219.
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spelling pubmed-81601252021-05-29 Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies Guo, Yang Li, Xiaosu Wang, Zhijian Yu, Bo Front Cardiovasc Med Cardiovascular Medicine Introduction: Hypertension is one of the major risk factors to human health and human studies on association between gut microbiota and hypertension or blood pressure have received increased attention. In the present study, we aim to evaluate gut microbiota dysbiosis in human hypertension using a method of systematic review. Methods: PubMed, EMBASE, and Web of Science databases were searched until March 2021 to identify eligible articles. Additional articles were also identified by searching specific authors in this field. Inclusion criteria were observational studies based on stool samples with hypertension group and control group. Newcastle-Ottawa quality assessment scale (NOS) was used to assess the quality of the included studies. PROSPERO registration number: CRD42020212219. Results: A total of 17 studies enrolling 9,085 participants were included. Fifteen of the enrolled studies showed good quality and two studies showed fair quality based on NOS. We found alpha diversity in hypertension decreased significantly and microbial structure can be separated compared with control groups. Gut microbiota of hypertension showed depletion of short chain fatty acids (SCFAs) producers and over-growth of some Proteobacteria and Bacteroidetes members. Up-regulation of lipopolysaccharide biosynthesis, phosphotransferase system, ABC transporters, etc. and down-regulation of some amino acid metabolism, etc. in hypertension were reported. Fecal SCFAs levels increased and plasma SCFAs levels decreased in hypertension. Stronger microbial interactions in hypertension were seen. Conclusion: In conclusion, gut microbiota dysbiosis was observed in hypertension, including decreased diversity, altered microbial structure, compositional change of taxa, alterations of microbial function, nutritional and immunological factors, and microbial interactions. Poor absorption and high excretion of SCFAs may play an important role in the pathogenesis of hypertension. These findings may provide insights into etiology study and new microbial-based therapies of hypertension. Systematic Review Registration: PROSPERO database, identifier CRD42020212219. Frontiers Media S.A. 2021-05-14 /pmc/articles/PMC8160125/ /pubmed/34055933 http://dx.doi.org/10.3389/fcvm.2021.650227 Text en Copyright © 2021 Guo, Li, Wang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Guo, Yang
Li, Xiaosu
Wang, Zhijian
Yu, Bo
Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title_full Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title_fullStr Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title_full_unstemmed Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title_short Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
title_sort gut microbiota dysbiosis in human hypertension: a systematic review of observational studies
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160125/
https://www.ncbi.nlm.nih.gov/pubmed/34055933
http://dx.doi.org/10.3389/fcvm.2021.650227
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