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Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient

COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hod...

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Autores principales: Sharma, Purva, Chakraborty, Kanishka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160192/
https://www.ncbi.nlm.nih.gov/pubmed/34039554
http://dx.doi.org/10.1136/bcr-2021-242921
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author Sharma, Purva
Chakraborty, Kanishka
author_facet Sharma, Purva
Chakraborty, Kanishka
author_sort Sharma, Purva
collection PubMed
description COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin’s lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection.
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spelling pubmed-81601922021-06-10 Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient Sharma, Purva Chakraborty, Kanishka BMJ Case Rep Case Report COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin’s lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection. BMJ Publishing Group 2021-05-26 /pmc/articles/PMC8160192/ /pubmed/34039554 http://dx.doi.org/10.1136/bcr-2021-242921 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Sharma, Purva
Chakraborty, Kanishka
Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title_full Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title_fullStr Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title_full_unstemmed Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title_short Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
title_sort delayed manifestation of extensive covid-19-associated coagulopathy in high-risk patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160192/
https://www.ncbi.nlm.nih.gov/pubmed/34039554
http://dx.doi.org/10.1136/bcr-2021-242921
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