Cargando…

Structures in G proteins important for subtype selective receptor binding and subsequent activation

G protein-coupled receptors (GPCRs) selectively couple to specific heterotrimeric G proteins comprised of four subfamilies in order to induce appropriate physiological responses. However, structural determinants in Gα subunits responsible for selective recognition by approximately 800 human GPCRs ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jelinek, Volker, Mösslein, Nadja, Bünemann, Moritz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160216/ https://www.ncbi.nlm.nih.gov/pubmed/34045638 http://dx.doi.org/10.1038/s42003-021-02143-9

Ejemplares similares

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor
por: Zhao, Li-Hua, et al.
Publicado: (2022)

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
por: Hedderich, Janik B., et al.
Publicado: (2022)

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
por: Suno, Ryoji, et al.
Publicado: (2018)

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
por: Duan, Jia, et al.
Publicado: (2022)

Disentangling bias between G(q), GRK2, and arrestin3 recruitment to the M(3) muscarinic acetylcholine receptor
por: Flöser, Anja, et al.
Publicado: (2021)

Interaction kinetics between p115-RhoGEF and Gα(13) are determined by unique molecular interactions affecting agonist sensitivity
por: Redlin, Fabian, et al.
Publicado: (2022)

A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts
por: Zhang, Bingjie, et al.
Publicado: (2020)

Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors
por: Karnam, Preethi C., et al.
Publicado: (2021)

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor
por: Al-Sabah, Suleiman, et al.
Publicado: (2020)

Correction to “A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts”
por: Zhang, Bingjie, et al.
Publicado: (2020)

Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands
por: Schaab, Carolin, et al.
Publicado: (2014)

Voltage modulates the effect of μ‐receptor activation in a ligand‐dependent manner
por: Ruland, Julia G., et al.
Publicado: (2020)

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors
por: Vu, Oanh, et al.
Publicado: (2021)

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
por: Booe, Jason M., et al.
Publicado: (2015)

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling
por: Zindel, Diana, et al.
Publicado: (2016)

Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors
por: Miyachi, Hiroyuki
Publicado: (2021)

The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors
por: Baade, Imke, et al.
Publicado: (2021)

Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors
por: Davies, Jonathan R., et al.
Publicado: (2020)

Structures of neurokinin 1 receptor in complex with G(q) and G(s) proteins reveal substance P binding mode and unique activation features
por: Thom, Cristian, et al.
Publicado: (2021)

G4-quadruplex-binding proteins: review and insights into selectivity
por: Meier-Stephenson, Vanessa
Publicado: (2022)

Recent Progress in Understanding Subtype Specific Regulation of NMDA Receptors by G Protein Coupled Receptors (GPCRs)
por: Yang, Kai, et al.
Publicado: (2014)

Vertebrates originally possess four functional subtypes of G protein-coupled melatonin receptor
por: Sakai, Kotowa, et al.
Publicado: (2019)

Structural prerequisites for G-protein activation by the neurotensin receptor
por: Krumm, Brian E., et al.
Publicado: (2015)

The Influence of AA29504 on GABA(A) Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity
por: Sikstus, Sylvia, et al.
Publicado: (2021)

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D(1) Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation
por: Moritz, Amy E., et al.
Publicado: (2023)

Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors
por: Dutta, Soumajit, et al.
Publicado: (2023)

The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively
por: Al-Sabah, Suleiman, et al.
Publicado: (2014)

XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity
por: Johansson, Linda C., et al.
Publicado: (2019)

Ligand and G-protein selectivity in the κ-opioid receptor
por: Han, Jianming, et al.
Publicado: (2023)

Ligand-Binding Affinity at the Insulin Receptor Isoform-A and Subsequent IR-A Tyrosine Phosphorylation Kinetics are Important Determinants of Mitogenic Biological Outcomes
por: Rajapaksha, Harinda, et al.
Publicado: (2015)

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors
por: Homan, Kristoff T., et al.
Publicado: (2014)

Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin-C Receptor with Its Endogenous Agonist
por: Işbilir, Ali, et al.
Publicado: (2020)

Protocol for identifying physiologically relevant binding proteins of G-protein-coupled receptors
por: Huang, Bill X., et al.
Publicado: (2023)

Structural Studies of G Protein-Coupled Receptors
por: Zhang, Dandan, et al.
Publicado: (2015)

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels
por: Dembla, Sandeep, et al.
Publicado: (2017)

A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands
por: Zhang, Jingxian, et al.
Publicado: (2012)

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors
por: Chin, Andrea, et al.
Publicado: (2022)

Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4
por: Börzsei, Rita, et al.
Publicado: (2022)

Importance of B Lymphocytes and the IgG-Binding Protein Sbi in Staphylococcus aureus Skin Infection
por: Zhao, Fan, et al.
Publicado: (2016)

Antiepileptic activity and subtype-selective action of flupirtine at GABA(A) receptors
por: Bajrić, Mirnes, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_724g0eo5u0ol6a2qnrgv73rlcr