Cargando…

The Functional Role of Sphingosine Kinase 2

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Diaz Escarcega, Rocio, McCullough, Louise D., Tsvetkov, Andrey S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160245/ https://www.ncbi.nlm.nih.gov/pubmed/34055895 http://dx.doi.org/10.3389/fmolb.2021.683767

Ejemplares similares

Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes
por: Moruno-Manchon, Jose F., et al.
Publicado: (2018)

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
por: Hii, Ling-Wei, et al.
Publicado: (2021)

Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin
por: Escarcega, Rocio Diaz, et al.
Publicado: (2023)

Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase
por: Ballard, Darby J., et al.
Publicado: (2021)

Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells
por: Nema, Rajeev, et al.
Publicado: (2021)

The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis
por: Obomighie, Irabonosi, et al.
Publicado: (2021)

Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties
por: Sala, Davide, et al.
Publicado: (2023)

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase
por: Ahmad, Bilal, et al.
Publicado: (2020)

A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases
por: Hajredini, Fatlum, et al.
Publicado: (2021)

Casein Kinase 2 Signaling in White Matter Stroke
por: Nguyen, Hung, et al.
Publicado: (2022)

Loss of Ca(2+)/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease
por: Sabbir, Mohammad Golam
Publicado: (2018)

Mechanistic insights into the role of calcium in the allosteric regulation of the calmodulin-regulated death-associated protein kinase
por: Li, Xiaolong, et al.
Publicado: (2022)

Copper Modulates the Catalytic Activity of Protein Kinase CK2
por: Chojnowski, John E., et al.
Publicado: (2022)

Protein Kinase A in cellular migration—Niche signaling of a ubiquitous kinase
por: Svec, Kathryn V., et al.
Publicado: (2022)

Circular RNAs: Biogenesis, Function and Role in Human Diseases
por: Greene, John, et al.
Publicado: (2017)

MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach
por: Stehn, Justine R., et al.
Publicado: (2023)

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

Synthesis and Preliminary Immunological Evaluation of a Pseudotetrasaccharide Related to a Repeating Unit of the Streptococcus pneumoniae Serotype 6A Capsular Polysaccharide
por: Sukhova, Elena V., et al.
Publicado: (2021)

Role of Copper on Mitochondrial Function and Metabolism
por: Ruiz, Lina M., et al.
Publicado: (2021)

G-Quadruplexes and the DNA/RNA helicase DHX36 in health, disease, and aging
por: Antcliff, Aaron, et al.
Publicado: (2021)

Critical roles of functional molecule metabolites
por: Liu, Peng, et al.
Publicado: (2023)

Structure and Characterization of a Covalent Inhibitor of Src Kinase
por: Gurbani, Deepak, et al.
Publicado: (2020)

Impact of Deleterious Mutations on Structure, Function and Stability of Serum/Glucocorticoid Regulated Kinase 1: A Gene to Diseases Correlation
por: AlAjmi, Mohamed F., et al.
Publicado: (2021)

Editorial: Casein kinases in human diseases
por: Venerando, Andrea, et al.
Publicado: (2022)

H(2)S Persulfidated and Increased Kinase Activity of MPK4 to Response Cold Stress in Arabidopsis
por: Du, Xinzhe, et al.
Publicado: (2021)

Implementing a Scoring Function Based on Interaction Fingerprint for Autogrow4: Protein Kinase CK1δ as a Case Study
por: Pavan, Matteo, et al.
Publicado: (2022)

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection
por: Nunes, J, et al.
Publicado: (2012)

Role of Transient Receptor Potential Vanilloid 4 in Vascular Function
por: Liu, Liangliang, et al.
Publicado: (2021)

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)
por: Behari, Jatin, et al.
Publicado: (2021)

Structural insights into the functional roles of 14-3-3 proteins
por: Obsilova, Veronika, et al.
Publicado: (2022)

The structural and functional roles of the flavin cofactor FAD in mammalian cryptochromes
por: Calloni, Giulia, et al.
Publicado: (2023)

The Okur-Chung Neurodevelopmental Syndrome Mutation CK2(K198R) Leads to a Rewiring of Kinase Specificity
por: Caefer, Danielle M., et al.
Publicado: (2022)

Inhibition of Protein Kinase CK2 Affects Thymidylate Synthesis Cycle Enzyme Level and Distribution in Human Cancer Cells
por: Wińska, Patrycja, et al.
Publicado: (2022)

The Role of Mitochondrial Dysfunction in Vascular Disease, Tumorigenesis, and Diabetes
por: Zhunina, Olga A., et al.
Publicado: (2021)

Peroxisomal Dysfunction in Neurological Diseases and Brain Aging
por: Uzor, Ndidi-Ese, et al.
Publicado: (2020)

Cellular ATP Levels Determine the Stability of a Nucleotide Kinase
por: Brylski, Oliver, et al.
Publicado: (2021)

Predicting the Specificity- Determining Positions of Receptor Tyrosine Kinase Axl
por: Karakulak, Tülay, et al.
Publicado: (2021)

LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer
por: Shkurnikov, Maxim, et al.
Publicado: (2019)

AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment
por: Singh, Shashi Prakash, et al.
Publicado: (2022)

Regulatory Non-coding RNAs for Death Associated Protein Kinase Family
por: Wang, Qingshui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a3d65ssqmglndipr1jmkg7qdg1