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Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men) treated b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160271/ https://www.ncbi.nlm.nih.gov/pubmed/34045528 http://dx.doi.org/10.1038/s41598-021-90508-9 |
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author | Yue, Xiaofei Jiang, Qiqi Hu, Xuehan Cen, Chunyuan Song, Songlin Qian, Kun Lu, Yuting Yang, Ming Li, Qian Han, Ping |
author_facet | Yue, Xiaofei Jiang, Qiqi Hu, Xuehan Cen, Chunyuan Song, Songlin Qian, Kun Lu, Yuting Yang, Ming Li, Qian Han, Ping |
author_sort | Yue, Xiaofei |
collection | PubMed |
description | We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men) treated by TACE who received contrast-enhanced DECT and were retreated by TACE within 7 days between November 2018 and December 2019. Taking digital subtraction angiography (DSA) and CT images as reference standard, two readers measured and calculated the values of normalized iodine concentration at arterial phase (NICAP), normalized iodine concentration at portal venous phase (NICPP), iodine concentration difference (ICD), arterial iodine fraction (AIF) and slope of the spectral Hounsfield unit curve (λ(Hu)) by placing matched regions of interests (ROIs) within the tumor active area (TAA), adjacent normal hepatic parenchyma (ANHP) and tumor necrotic area (TNA). Differences between the parameters were analyzed by the Kruskal–Wallis H test. Receiver operating characteristic analysis of the parameters performance in differentiating the three tissues types was performed. AIF exhibited a good performance in distinguishing TAA (0.93 ± 0.31) and ANHP (0.18 ± 0.14), the areas under the receiver operating characteristic curve (AUC) was 0.989, while the λ(Hu) exhibited an excellent performance in distinguishing TAA (3.32 ± 1.24) and TNA (0.29 ± 0.27), with an AUC of 1.000. In conclusion, quantitative DECT can be effectively used to evaluate the tumor viability in HCC patients treated by TACE. |
format | Online Article Text |
id | pubmed-8160271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81602712021-06-01 Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization Yue, Xiaofei Jiang, Qiqi Hu, Xuehan Cen, Chunyuan Song, Songlin Qian, Kun Lu, Yuting Yang, Ming Li, Qian Han, Ping Sci Rep Article We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men) treated by TACE who received contrast-enhanced DECT and were retreated by TACE within 7 days between November 2018 and December 2019. Taking digital subtraction angiography (DSA) and CT images as reference standard, two readers measured and calculated the values of normalized iodine concentration at arterial phase (NICAP), normalized iodine concentration at portal venous phase (NICPP), iodine concentration difference (ICD), arterial iodine fraction (AIF) and slope of the spectral Hounsfield unit curve (λ(Hu)) by placing matched regions of interests (ROIs) within the tumor active area (TAA), adjacent normal hepatic parenchyma (ANHP) and tumor necrotic area (TNA). Differences between the parameters were analyzed by the Kruskal–Wallis H test. Receiver operating characteristic analysis of the parameters performance in differentiating the three tissues types was performed. AIF exhibited a good performance in distinguishing TAA (0.93 ± 0.31) and ANHP (0.18 ± 0.14), the areas under the receiver operating characteristic curve (AUC) was 0.989, while the λ(Hu) exhibited an excellent performance in distinguishing TAA (3.32 ± 1.24) and TNA (0.29 ± 0.27), with an AUC of 1.000. In conclusion, quantitative DECT can be effectively used to evaluate the tumor viability in HCC patients treated by TACE. Nature Publishing Group UK 2021-05-27 /pmc/articles/PMC8160271/ /pubmed/34045528 http://dx.doi.org/10.1038/s41598-021-90508-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yue, Xiaofei Jiang, Qiqi Hu, Xuehan Cen, Chunyuan Song, Songlin Qian, Kun Lu, Yuting Yang, Ming Li, Qian Han, Ping Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title | Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title_full | Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title_fullStr | Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title_full_unstemmed | Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title_short | Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization |
title_sort | quantitative dual-energy ct for evaluating hepatocellular carcinoma after transarterial chemoembolization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160271/ https://www.ncbi.nlm.nih.gov/pubmed/34045528 http://dx.doi.org/10.1038/s41598-021-90508-9 |
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