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Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand

To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was rev...

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Autores principales: Dhirachaikulpanich, Dhanach, Soraprajum, Kunravitch, Boonsopon, Sutasinee, Pinitpuwadol, Warinyupa, Lourthai, Preeyachan, Punyayingyong, Noppakhun, Tesavibul, Nattaporn, Choopong, Pitipol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160326/
https://www.ncbi.nlm.nih.gov/pubmed/34045630
http://dx.doi.org/10.1038/s41598-021-90815-1
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author Dhirachaikulpanich, Dhanach
Soraprajum, Kunravitch
Boonsopon, Sutasinee
Pinitpuwadol, Warinyupa
Lourthai, Preeyachan
Punyayingyong, Noppakhun
Tesavibul, Nattaporn
Choopong, Pitipol
author_facet Dhirachaikulpanich, Dhanach
Soraprajum, Kunravitch
Boonsopon, Sutasinee
Pinitpuwadol, Warinyupa
Lourthai, Preeyachan
Punyayingyong, Noppakhun
Tesavibul, Nattaporn
Choopong, Pitipol
author_sort Dhirachaikulpanich, Dhanach
collection PubMed
description To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was reviewed. Only endophthalmitis cases with previous corneal or scleral infection were included in the study. The patients were followed until losing vision or eyeball, becoming phthisis, or the end of 2018. Eighty-seven patients with KSE were identified, all unilateral. The mean age was 56.4 ± 21.4 years. There was a slight male predilection (55 patients, 63.2%). The mean follow-up time was 50 ± 149 weeks. The causative pathogens were identified in 35 patients (40.2%), with the highest frequency being bacteria. The most common bacterium was Pseudomonas aeruginosa (n = 13), and the most common fungus was Aspergillus sp. (n = 5). Fifteen patients achieved (17.2%) final visual acuity (VA) of hand motion or better after treatment. Eyeball removal was performed in 61 (70.1%) patients. From multivariate analysis, the only prognostic factor for poor final VA (worse than hand motion, HM) was poor VA (worse than HM) at the initial visit (relative risk 1.97, 95% confidence interval 1.15–3.36, p = 0.013). KSE is uncommon but has a devastating outcome. We found that the patient’s initial VA was the only predictor for their final vision. P. aeruginosa was the most common identifiable organism in this study. However, several fungal infections were recognised. These findings should raise awareness for treatment of KSE in the tropics.
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spelling pubmed-81603262021-06-01 Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand Dhirachaikulpanich, Dhanach Soraprajum, Kunravitch Boonsopon, Sutasinee Pinitpuwadol, Warinyupa Lourthai, Preeyachan Punyayingyong, Noppakhun Tesavibul, Nattaporn Choopong, Pitipol Sci Rep Article To demonstrate the demographics, associated factors, clinical presentations, microbiology, management, visual outcome and complications of keratitis/scleritis-related endophthalmitis (KSE). A retrospective chart of all endophthalmitis patients diagnosed between September 2001 and August 2011 was reviewed. Only endophthalmitis cases with previous corneal or scleral infection were included in the study. The patients were followed until losing vision or eyeball, becoming phthisis, or the end of 2018. Eighty-seven patients with KSE were identified, all unilateral. The mean age was 56.4 ± 21.4 years. There was a slight male predilection (55 patients, 63.2%). The mean follow-up time was 50 ± 149 weeks. The causative pathogens were identified in 35 patients (40.2%), with the highest frequency being bacteria. The most common bacterium was Pseudomonas aeruginosa (n = 13), and the most common fungus was Aspergillus sp. (n = 5). Fifteen patients achieved (17.2%) final visual acuity (VA) of hand motion or better after treatment. Eyeball removal was performed in 61 (70.1%) patients. From multivariate analysis, the only prognostic factor for poor final VA (worse than hand motion, HM) was poor VA (worse than HM) at the initial visit (relative risk 1.97, 95% confidence interval 1.15–3.36, p = 0.013). KSE is uncommon but has a devastating outcome. We found that the patient’s initial VA was the only predictor for their final vision. P. aeruginosa was the most common identifiable organism in this study. However, several fungal infections were recognised. These findings should raise awareness for treatment of KSE in the tropics. Nature Publishing Group UK 2021-05-27 /pmc/articles/PMC8160326/ /pubmed/34045630 http://dx.doi.org/10.1038/s41598-021-90815-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dhirachaikulpanich, Dhanach
Soraprajum, Kunravitch
Boonsopon, Sutasinee
Pinitpuwadol, Warinyupa
Lourthai, Preeyachan
Punyayingyong, Noppakhun
Tesavibul, Nattaporn
Choopong, Pitipol
Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_full Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_fullStr Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_full_unstemmed Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_short Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand
title_sort epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in thailand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160326/
https://www.ncbi.nlm.nih.gov/pubmed/34045630
http://dx.doi.org/10.1038/s41598-021-90815-1
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