Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa

Increased IgE is a typical feature of allergic rhinitis. Local class-switch recombination has been intimated but B cell precursors and mechanisms remain elusive. Here we describe the dynamics underlying the generation of IgE-antibody secreting cells (ASC) in human nasal polyps (NP), mucosal tissues...

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Detalles Bibliográficos
Autores principales: Corrado, Alessia, Ramonell, Richard P., Woodruff, Matthew C., Tipton, Christopher, Wise, Sarah, Levy, Joshua, DelGaudio, John, Kuruvilla, Merin E., Magliocca, Kelly R., Tomar, Deepak, Garimalla, Swetha, Scharer, Christopher D., Boss, Jeremy M., Wu, Hao, Gumber, Sanjeev, Fucile, Chris, Gibson, Greg, Rosenberg, Alexander, Sanz, Iñaki, Lee, F. Eun-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160425/
https://www.ncbi.nlm.nih.gov/pubmed/34050324
http://dx.doi.org/10.1038/s41385-021-00410-w

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