Cargando…

A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer’s Disease Model Mice

We investigated the effects of a heptapeptide, GPPGPAG, on memory improvement and neuritic regeneration in Alzheimer’s disease models to evaluate its potency as a new anti-Alzheimer’s disease (AD) therapy. The anti-AD effects of GPPGPAG were evaluated in Aβ-treated cortical neurons and 5XFAD, a mous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tohda, Chihiro, Kogure, Chisato, Nomoto, Kaori, de Toledo, Andreia, Yang, Ximeng, Hirano, Eiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160438/ https://www.ncbi.nlm.nih.gov/pubmed/34054554 http://dx.doi.org/10.3389/fphar.2021.680652

Ejemplares similares

Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β
por: de Toledo, Andreia, et al.
Publicado: (2021)

Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
por: Yang, Ximeng, et al.
Publicado: (2023)

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease
por: Yang, Ximeng, et al.
Publicado: (2018)

Skeletal muscle atrophy‐induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease
por: Nagase, Tsukasa, et al.
Publicado: (2021)

Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease
por: Kuboyama, Tomoharu, et al.
Publicado: (2020)

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule
por: Farid, Mai M., et al.
Publicado: (2020)

New Treatment for Alzheimer's Disease, Kamikihito, Reverses Amyloid-β-Induced Progression of Tau Phosphorylation and Axonal Atrophy
por: Watari, Hidetoshi, et al.
Publicado: (2014)

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70)
por: Yang, Ximeng, et al.
Publicado: (2018)

Atomistic fibrillar architectures of polar prion-inspired heptapeptides
por: Peccati, Francesca, et al.
Publicado: (2020)

Effects of Cistanche tubulosa Wight Extract on Locomotive Syndrome: A Placebo-Controlled, Randomized, Double-Blind Study
por: Inada, Yuna, et al.
Publicado: (2021)

Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain
por: Yamauchi, Yui, et al.
Publicado: (2019)

Modified heptapeptide from tau binds both tubulin and microtubules
por: Li, Jingrui, et al.
Publicado: (2020)

Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates
por: Abo-Ghalia, Mohamed H., et al.
Publicado: (2020)

Effects of a Particular Heptapeptide on the IFN-α-Sensitive CML Cells
por: Yang, Fu-lan, et al.
Publicado: (2015)

Identification and Characterization of Novel Fc-Binding Heptapeptides from Experiments and Simulations
por: Sun, Xiaoquan, et al.
Publicado: (2018)

Screening of an annexin‐A2‐targeted heptapeptide for pancreatic adenocarcinoma localization
por: Ma, Heyao, et al.
Publicado: (2022)

Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury
por: Kodani, Atsushi, et al.
Publicado: (2019)

Brain-targeted heptapeptide-loaded exosomes attenuated ischemia–reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons
por: Liu, Wei, et al.
Publicado: (2022)

Effect of TMAO and Urea on Dimers and Tetramers of Amyloidogenic Heptapeptides ((23)FGAILSS(29))
por: Khan, Ashma, et al.
Publicado: (2020)

The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli
por: Ran, Rensen, et al.
Publicado: (2017)

Identification of Specific Hydroxyapatite {001} Binding Heptapeptide by Phage Display and Its Nucleation Effect
por: Mao, Jing, et al.
Publicado: (2016)

Conformational Ensembles by NMR and MD Simulations in Model Heptapeptides with Select Tri-Peptide Motifs
por: Krishnan, V. V., et al.
Publicado: (2021)

Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy
por: Awale, Suresh, et al.
Publicado: (2011)

Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides
por: Bouillaut, L., et al.
Publicado: (2008)

Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp.
por: Wu, Guangwei, et al.
Publicado: (2017)

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
por: Zorzi, Alessandro, et al.
Publicado: (2017)

Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach
por: Zhang, Xiaoyan, et al.
Publicado: (2022)

A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule
por: Yang, Zhiyou, et al.
Publicado: (2017)

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil
por: Donalle, Guidmar C., et al.
Publicado: (2022)

Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults
por: Tohda, Chihiro, et al.
Publicado: (2020)

Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer's Disease Patients
por: Watari, Hidetoshi, et al.
Publicado: (2019)

Editorial: Treatment of Alzheimer’s disease-discovery of natural products based on neurite outgrowth and neuroprotection
por: Yang, Zhiyou, et al.
Publicado: (2022)

Polymeric nanoparticles conjugate a novel heptapeptide as an epidermal growth factor receptor-active targeting ligand for doxorubicin
por: Liu, Chia Wen, et al.
Publicado: (2012)

A Novel Carboxyl-Terminal Heptapeptide Initiates the Regulated Secretion of LH from Unique Sub-Domains of the ER
por: Jablonka-Shariff, Albina, et al.
Publicado: (2013)

Certain heptapeptide and large sequences representing an entire helix, strand or coil conformation in proteins are associated as chameleon sequences
por: Krishna, Neethu, et al.
Publicado: (2011)

An angiotensin-converting enzyme-2-derived heptapeptide GK-7 for SARS-CoV-2 spike blockade
por: Han, Songling, et al.
Publicado: (2021)

Purification and Characterization of a Novel Calcium-Binding Heptapeptide from the Hydrolysate of Tilapia Bone with Its Osteogenic Activity
por: He, Jinlun, et al.
Publicado: (2022)

Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults
por: Tohda, Chihiro, et al.
Publicado: (2017)

Extracellular cathepsin L stimulates axonal growth in neurons
por: Tohda, Chihiro, et al.
Publicado: (2017)

The immunomodulatory functions and molecular mechanism of a new bursal heptapeptide (BP7) in immune responses and immature B cells
por: Feng, Xiu Li, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tm8bgml6p7l8fpc5blikqs1a46