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Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules

Sleep disturbances and memory dysfunction are key characteristics across psychiatric disorders. Recent advances have revealed insight into the role of sleep in memory consolidation, pointing to key overlap between memory consolidation processes and structural and molecular abnormalities in psychiatr...

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Autores principales: Gisabella, Barbara, Babu, Jobin, Valeri, Jake, Rexrode, Lindsay, Pantazopoulos, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160443/
https://www.ncbi.nlm.nih.gov/pubmed/34054408
http://dx.doi.org/10.3389/fnins.2021.646678
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author Gisabella, Barbara
Babu, Jobin
Valeri, Jake
Rexrode, Lindsay
Pantazopoulos, Harry
author_facet Gisabella, Barbara
Babu, Jobin
Valeri, Jake
Rexrode, Lindsay
Pantazopoulos, Harry
author_sort Gisabella, Barbara
collection PubMed
description Sleep disturbances and memory dysfunction are key characteristics across psychiatric disorders. Recent advances have revealed insight into the role of sleep in memory consolidation, pointing to key overlap between memory consolidation processes and structural and molecular abnormalities in psychiatric disorders. Ongoing research regarding the molecular mechanisms involved in memory consolidation has the potential to identify therapeutic targets for memory dysfunction in psychiatric disorders and aging. Recent evidence from our group and others points to extracellular matrix molecules, including chondroitin sulfate proteoglycans and their endogenous proteases, as molecules that may underlie synaptic dysfunction in psychiatric disorders and memory consolidation during sleep. These molecules may provide a therapeutic targets for decreasing strength of reward memories in addiction and traumatic memories in PTSD, as well as restoring deficits in memory consolidation in schizophrenia and aging. We review the evidence for sleep and memory consolidation dysfunction in psychiatric disorders and aging in the context of current evidence pointing to the involvement of extracellular matrix molecules in these processes.
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spelling pubmed-81604432021-05-29 Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules Gisabella, Barbara Babu, Jobin Valeri, Jake Rexrode, Lindsay Pantazopoulos, Harry Front Neurosci Neuroscience Sleep disturbances and memory dysfunction are key characteristics across psychiatric disorders. Recent advances have revealed insight into the role of sleep in memory consolidation, pointing to key overlap between memory consolidation processes and structural and molecular abnormalities in psychiatric disorders. Ongoing research regarding the molecular mechanisms involved in memory consolidation has the potential to identify therapeutic targets for memory dysfunction in psychiatric disorders and aging. Recent evidence from our group and others points to extracellular matrix molecules, including chondroitin sulfate proteoglycans and their endogenous proteases, as molecules that may underlie synaptic dysfunction in psychiatric disorders and memory consolidation during sleep. These molecules may provide a therapeutic targets for decreasing strength of reward memories in addiction and traumatic memories in PTSD, as well as restoring deficits in memory consolidation in schizophrenia and aging. We review the evidence for sleep and memory consolidation dysfunction in psychiatric disorders and aging in the context of current evidence pointing to the involvement of extracellular matrix molecules in these processes. Frontiers Media S.A. 2021-05-14 /pmc/articles/PMC8160443/ /pubmed/34054408 http://dx.doi.org/10.3389/fnins.2021.646678 Text en Copyright © 2021 Gisabella, Babu, Valeri, Rexrode and Pantazopoulos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gisabella, Barbara
Babu, Jobin
Valeri, Jake
Rexrode, Lindsay
Pantazopoulos, Harry
Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title_full Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title_fullStr Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title_full_unstemmed Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title_short Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules
title_sort sleep and memory consolidation dysfunction in psychiatric disorders: evidence for the involvement of extracellular matrix molecules
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160443/
https://www.ncbi.nlm.nih.gov/pubmed/34054408
http://dx.doi.org/10.3389/fnins.2021.646678
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