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A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis

Non-infectious uveitis is an inflammatory disorder of the eye that accounts for severe visual loss without evident infectious agents. While T cells are supposed to dominate the induction of inflammation in non-infectious uveitis, the role of B cells in the pathogenesis of this disease is obscure. Th...

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Autores principales: Zhu, Lei, Chen, Binyao, Su, Wenru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160461/
https://www.ncbi.nlm.nih.gov/pubmed/34054864
http://dx.doi.org/10.3389/fimmu.2021.676046
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author Zhu, Lei
Chen, Binyao
Su, Wenru
author_facet Zhu, Lei
Chen, Binyao
Su, Wenru
author_sort Zhu, Lei
collection PubMed
description Non-infectious uveitis is an inflammatory disorder of the eye that accounts for severe visual loss without evident infectious agents. While T cells are supposed to dominate the induction of inflammation in non-infectious uveitis, the role of B cells in the pathogenesis of this disease is obscure. Therefore, this review aimed to discuss diverse B-cell participation in different non-infectious uveitides and their roles in the pathogenesis of this disease as well as the mechanism of action of rituximab. Increasing evidence from experimental models and human non-infectious uveitis has suggested the participation of B cells in non-infectious uveitis. The participation levels vary in different uveitides. Furthermore, B cells play multiple roles in the pathogenic mechanisms. B cells produce autoantibodies, regulate T cell responses via antibody-independent functions, and constitute ectopic lymphoid structures. Regulatory B cells perform pivotal anti-inflammatory functions in non-infectious uveitis. Rituximab may work by depleting pro-inflammatory B cells and restoring the quantity and function of regulatory B cells in this disease. Identifying the levels of B-cell participation and the associated roles is beneficial for optimizing therapy. Diversified experimental model choices and emerging tools and/or methods are conducive for future studies on this topic.
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spelling pubmed-81604612021-05-29 A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis Zhu, Lei Chen, Binyao Su, Wenru Front Immunol Immunology Non-infectious uveitis is an inflammatory disorder of the eye that accounts for severe visual loss without evident infectious agents. While T cells are supposed to dominate the induction of inflammation in non-infectious uveitis, the role of B cells in the pathogenesis of this disease is obscure. Therefore, this review aimed to discuss diverse B-cell participation in different non-infectious uveitides and their roles in the pathogenesis of this disease as well as the mechanism of action of rituximab. Increasing evidence from experimental models and human non-infectious uveitis has suggested the participation of B cells in non-infectious uveitis. The participation levels vary in different uveitides. Furthermore, B cells play multiple roles in the pathogenic mechanisms. B cells produce autoantibodies, regulate T cell responses via antibody-independent functions, and constitute ectopic lymphoid structures. Regulatory B cells perform pivotal anti-inflammatory functions in non-infectious uveitis. Rituximab may work by depleting pro-inflammatory B cells and restoring the quantity and function of regulatory B cells in this disease. Identifying the levels of B-cell participation and the associated roles is beneficial for optimizing therapy. Diversified experimental model choices and emerging tools and/or methods are conducive for future studies on this topic. Frontiers Media S.A. 2021-05-14 /pmc/articles/PMC8160461/ /pubmed/34054864 http://dx.doi.org/10.3389/fimmu.2021.676046 Text en Copyright © 2021 Zhu, Chen and Su https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhu, Lei
Chen, Binyao
Su, Wenru
A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title_full A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title_fullStr A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title_full_unstemmed A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title_short A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
title_sort review of the various roles and participation levels of b-cells in non-infectious uveitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160461/
https://www.ncbi.nlm.nih.gov/pubmed/34054864
http://dx.doi.org/10.3389/fimmu.2021.676046
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