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Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study

Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM−IgG antibo...

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Detalles Bibliográficos
Autores principales: de Souza Araújo, Adriano Antunes, Quintans-Júnior, Lucindo José, Heimfarth, Luana, Schimieguel, Dulce Marta, Corrêa, Cristiane Bani, de Moura, Tatiana Rodrigues, Cavalcante, Rafael Ciro Marques, Rodrigues Bomfim, Rangel, Grespan, Renata, Santana Rodrigues, Lorranny, dos Santos, Danillo Menezes, de Sá Resende, Ayane, de Lima Silva, Nathanielly, da Silva Santos, Anna Clara Ramos, Dantas Araújo, Jéssica Maria, de Souza, Mércia Feitosa, de Oliveira Góes, Marco Aurélio, Santana Santos, Victor, Martins-Filho, Paulo Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160491/
https://www.ncbi.nlm.nih.gov/pubmed/34001292
http://dx.doi.org/10.1017/S0950268821001163
Descripción
Sumario:Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM−IgG antibody test and fluorescence immunoassay. The seroprevalence was 9.3% (95% CI 8.5–10.1), 10.2% (95% CI 9.2–11.3) for women and 7.9% (IC 95% 6.8–9.1) for men (P = 0.004). We found a decline in the prevalence of SARS-CoV-2 antibodies according to age, but the differences were not statistically significant: 0–19 years (9.9%; 95% CI 7.8–12.5), 20–59 years (9.3%; 95% CI 8.4–10.3) and ≥60 years (9.0%; 95% CI 7.5–10.8) (P = 0.517). The metropolitan area had a higher seroprevalence (11.7%, 95% CI 10.3–13.2) than outside municipalities (8.0%, 95% CI 7.2–8.9) (P < 0.001). These findings highlight the importance of serosurveillance to estimate the real impact of the COVID-19 outbreak and thereby provide data to better understand the spread of the virus, as well as providing information to guide stay-at-home measures and other policies. In addition, these results may be useful as basic data to follow the progress of COVID-19 outbreak as social restriction initiatives start to be relaxed in Brazil.