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Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study

Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM−IgG antibo...

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Autores principales: de Souza Araújo, Adriano Antunes, Quintans-Júnior, Lucindo José, Heimfarth, Luana, Schimieguel, Dulce Marta, Corrêa, Cristiane Bani, de Moura, Tatiana Rodrigues, Cavalcante, Rafael Ciro Marques, Rodrigues Bomfim, Rangel, Grespan, Renata, Santana Rodrigues, Lorranny, dos Santos, Danillo Menezes, de Sá Resende, Ayane, de Lima Silva, Nathanielly, da Silva Santos, Anna Clara Ramos, Dantas Araújo, Jéssica Maria, de Souza, Mércia Feitosa, de Oliveira Góes, Marco Aurélio, Santana Santos, Victor, Martins-Filho, Paulo Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160491/
https://www.ncbi.nlm.nih.gov/pubmed/34001292
http://dx.doi.org/10.1017/S0950268821001163
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author de Souza Araújo, Adriano Antunes
Quintans-Júnior, Lucindo José
Heimfarth, Luana
Schimieguel, Dulce Marta
Corrêa, Cristiane Bani
de Moura, Tatiana Rodrigues
Cavalcante, Rafael Ciro Marques
Rodrigues Bomfim, Rangel
Grespan, Renata
Santana Rodrigues, Lorranny
dos Santos, Danillo Menezes
de Sá Resende, Ayane
de Lima Silva, Nathanielly
da Silva Santos, Anna Clara Ramos
Dantas Araújo, Jéssica Maria
de Souza, Mércia Feitosa
de Oliveira Góes, Marco Aurélio
Santana Santos, Victor
Martins-Filho, Paulo Ricardo
author_facet de Souza Araújo, Adriano Antunes
Quintans-Júnior, Lucindo José
Heimfarth, Luana
Schimieguel, Dulce Marta
Corrêa, Cristiane Bani
de Moura, Tatiana Rodrigues
Cavalcante, Rafael Ciro Marques
Rodrigues Bomfim, Rangel
Grespan, Renata
Santana Rodrigues, Lorranny
dos Santos, Danillo Menezes
de Sá Resende, Ayane
de Lima Silva, Nathanielly
da Silva Santos, Anna Clara Ramos
Dantas Araújo, Jéssica Maria
de Souza, Mércia Feitosa
de Oliveira Góes, Marco Aurélio
Santana Santos, Victor
Martins-Filho, Paulo Ricardo
author_sort de Souza Araújo, Adriano Antunes
collection PubMed
description Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM−IgG antibody test and fluorescence immunoassay. The seroprevalence was 9.3% (95% CI 8.5–10.1), 10.2% (95% CI 9.2–11.3) for women and 7.9% (IC 95% 6.8–9.1) for men (P = 0.004). We found a decline in the prevalence of SARS-CoV-2 antibodies according to age, but the differences were not statistically significant: 0–19 years (9.9%; 95% CI 7.8–12.5), 20–59 years (9.3%; 95% CI 8.4–10.3) and ≥60 years (9.0%; 95% CI 7.5–10.8) (P = 0.517). The metropolitan area had a higher seroprevalence (11.7%, 95% CI 10.3–13.2) than outside municipalities (8.0%, 95% CI 7.2–8.9) (P < 0.001). These findings highlight the importance of serosurveillance to estimate the real impact of the COVID-19 outbreak and thereby provide data to better understand the spread of the virus, as well as providing information to guide stay-at-home measures and other policies. In addition, these results may be useful as basic data to follow the progress of COVID-19 outbreak as social restriction initiatives start to be relaxed in Brazil.
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spelling pubmed-81604912021-05-28 Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study de Souza Araújo, Adriano Antunes Quintans-Júnior, Lucindo José Heimfarth, Luana Schimieguel, Dulce Marta Corrêa, Cristiane Bani de Moura, Tatiana Rodrigues Cavalcante, Rafael Ciro Marques Rodrigues Bomfim, Rangel Grespan, Renata Santana Rodrigues, Lorranny dos Santos, Danillo Menezes de Sá Resende, Ayane de Lima Silva, Nathanielly da Silva Santos, Anna Clara Ramos Dantas Araújo, Jéssica Maria de Souza, Mércia Feitosa de Oliveira Góes, Marco Aurélio Santana Santos, Victor Martins-Filho, Paulo Ricardo Epidemiol Infect Original Paper Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM−IgG antibody test and fluorescence immunoassay. The seroprevalence was 9.3% (95% CI 8.5–10.1), 10.2% (95% CI 9.2–11.3) for women and 7.9% (IC 95% 6.8–9.1) for men (P = 0.004). We found a decline in the prevalence of SARS-CoV-2 antibodies according to age, but the differences were not statistically significant: 0–19 years (9.9%; 95% CI 7.8–12.5), 20–59 years (9.3%; 95% CI 8.4–10.3) and ≥60 years (9.0%; 95% CI 7.5–10.8) (P = 0.517). The metropolitan area had a higher seroprevalence (11.7%, 95% CI 10.3–13.2) than outside municipalities (8.0%, 95% CI 7.2–8.9) (P < 0.001). These findings highlight the importance of serosurveillance to estimate the real impact of the COVID-19 outbreak and thereby provide data to better understand the spread of the virus, as well as providing information to guide stay-at-home measures and other policies. In addition, these results may be useful as basic data to follow the progress of COVID-19 outbreak as social restriction initiatives start to be relaxed in Brazil. Cambridge University Press 2021-05-18 /pmc/articles/PMC8160491/ /pubmed/34001292 http://dx.doi.org/10.1017/S0950268821001163 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
de Souza Araújo, Adriano Antunes
Quintans-Júnior, Lucindo José
Heimfarth, Luana
Schimieguel, Dulce Marta
Corrêa, Cristiane Bani
de Moura, Tatiana Rodrigues
Cavalcante, Rafael Ciro Marques
Rodrigues Bomfim, Rangel
Grespan, Renata
Santana Rodrigues, Lorranny
dos Santos, Danillo Menezes
de Sá Resende, Ayane
de Lima Silva, Nathanielly
da Silva Santos, Anna Clara Ramos
Dantas Araújo, Jéssica Maria
de Souza, Mércia Feitosa
de Oliveira Góes, Marco Aurélio
Santana Santos, Victor
Martins-Filho, Paulo Ricardo
Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title_full Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title_fullStr Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title_full_unstemmed Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title_short Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study
title_sort seroprevalence of sars-cov-2 antibodies in the poorest region of brazil: results from a population-based study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160491/
https://www.ncbi.nlm.nih.gov/pubmed/34001292
http://dx.doi.org/10.1017/S0950268821001163
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