Taking regulatory T cells into medicine

Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations in function are causative of various monogenic and polygenic autoimmune diseases. Treg-based reestablishment of self-tolerance is envisioned to cu...

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Detalles Bibliográficos
Autor principal: Sakaguchi, Shimon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160581/
https://www.ncbi.nlm.nih.gov/pubmed/34037676
http://dx.doi.org/10.1084/jem.20210831
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author Sakaguchi, Shimon
author_facet Sakaguchi, Shimon
author_sort Sakaguchi, Shimon
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description Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations in function are causative of various monogenic and polygenic autoimmune diseases. Treg-based reestablishment of self-tolerance is envisioned to cure autoimmune diseases in the clinic.
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spelling pubmed-81605812021-12-07 Taking regulatory T cells into medicine Sakaguchi, Shimon J Exp Med Viewpoint Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations in function are causative of various monogenic and polygenic autoimmune diseases. Treg-based reestablishment of self-tolerance is envisioned to cure autoimmune diseases in the clinic. Rockefeller University Press 2021-05-26 /pmc/articles/PMC8160581/ /pubmed/34037676 http://dx.doi.org/10.1084/jem.20210831 Text en © 2021 Sakaguchi http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Sakaguchi, Shimon
Taking regulatory T cells into medicine
title Taking regulatory T cells into medicine
title_full Taking regulatory T cells into medicine
title_fullStr Taking regulatory T cells into medicine
title_full_unstemmed Taking regulatory T cells into medicine
title_short Taking regulatory T cells into medicine
title_sort taking regulatory t cells into medicine
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160581/
https://www.ncbi.nlm.nih.gov/pubmed/34037676
http://dx.doi.org/10.1084/jem.20210831
work_keys_str_mv AT sakaguchishimon takingregulatorytcellsintomedicine

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