Sterilizing immunity: New opportunities for rational TB vaccine design

Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector...

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Detalles Bibliográficos
Autores principales: Sher, Alan, Flynn, Joanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160586/
https://www.ncbi.nlm.nih.gov/pubmed/34037668
http://dx.doi.org/10.1084/jem.20210454
Descripción
Sumario:Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector mechanisms that when triggered by appropriately engineered vaccines could end TB’s deadly reign.

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