Sterilizing immunity: New opportunities for rational TB vaccine design

Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector...

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Detalles Bibliográficos
Autores principales: Sher, Alan, Flynn, Joanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160586/
https://www.ncbi.nlm.nih.gov/pubmed/34037668
http://dx.doi.org/10.1084/jem.20210454
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author Sher, Alan
Flynn, Joanne L.
author_facet Sher, Alan
Flynn, Joanne L.
author_sort Sher, Alan
collection PubMed
description Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector mechanisms that when triggered by appropriately engineered vaccines could end TB’s deadly reign.
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spelling pubmed-81605862022-01-05 Sterilizing immunity: New opportunities for rational TB vaccine design Sher, Alan Flynn, Joanne L. J Exp Med Viewpoint Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector mechanisms that when triggered by appropriately engineered vaccines could end TB’s deadly reign. Rockefeller University Press 2021-05-26 /pmc/articles/PMC8160586/ /pubmed/34037668 http://dx.doi.org/10.1084/jem.20210454 Text en © 2021 Sher and Flynn http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Sher, Alan
Flynn, Joanne L.
Sterilizing immunity: New opportunities for rational TB vaccine design
title Sterilizing immunity: New opportunities for rational TB vaccine design
title_full Sterilizing immunity: New opportunities for rational TB vaccine design
title_fullStr Sterilizing immunity: New opportunities for rational TB vaccine design
title_full_unstemmed Sterilizing immunity: New opportunities for rational TB vaccine design
title_short Sterilizing immunity: New opportunities for rational TB vaccine design
title_sort sterilizing immunity: new opportunities for rational tb vaccine design
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160586/
https://www.ncbi.nlm.nih.gov/pubmed/34037668
http://dx.doi.org/10.1084/jem.20210454
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