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Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study

BACKGROUND: Cytomegalovirus (CMV) is the most common viral pathogen after liver transplantation (LT). Although reactivation of CMV infection is generally described in the context of immunosuppression, it has also been described in critically ill immunocompetent patients including cirrhotic patients....

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Autores principales: Stadnik, Claudio Marcel B, Caurio, Cassia Ferreira B, Rodrigues-Filho, Edison M, Nedel, Wagner L, Cantisani, Guido PC, Zanotelli, Maria L, Pasqualotto, Alessandro C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160598/
https://www.ncbi.nlm.nih.gov/pubmed/34084592
http://dx.doi.org/10.4291/wjgp.v12.i3.51
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author Stadnik, Claudio Marcel B
Caurio, Cassia Ferreira B
Rodrigues-Filho, Edison M
Nedel, Wagner L
Cantisani, Guido PC
Zanotelli, Maria L
Pasqualotto, Alessandro C
author_facet Stadnik, Claudio Marcel B
Caurio, Cassia Ferreira B
Rodrigues-Filho, Edison M
Nedel, Wagner L
Cantisani, Guido PC
Zanotelli, Maria L
Pasqualotto, Alessandro C
author_sort Stadnik, Claudio Marcel B
collection PubMed
description BACKGROUND: Cytomegalovirus (CMV) is the most common viral pathogen after liver transplantation (LT). Although reactivation of CMV infection is generally described in the context of immunosuppression, it has also been described in critically ill immunocompetent patients including cirrhotic patients. AIM: To determine the incidence of reactivated CMV prior to LT. METHODS: This was a prospective cohort study evaluating adult patients who underwent LT between 2014 and 2016. A plasma sample was obtained from all patients for CMV quantitative real-time PCR testing right before transplantation. Patients were followed for at least 1 year to assess the following outcomes: Incidence of CMV infection, organ rejection and overall mortality. RESULTS: A total of 72 patients were enrolled. Four patients died before transplantation, thus 68 patients were followed up for a median of 44 mo (20-50 mo). In 23/72 patients (31.9%) CMV was reactivated before transplantation. Post-transplantation, 16/68 (23.5%) patients had CMV infection and that was significantly associated with the recipient being CMV negative and a CMV-positive donor. Pre-transplant CMV reactivation was not associated with overall mortality (log rank: 0.9). CONCLUSION: This study shows that CMV infection is common in patients with chronic liver disease just before LT, but the clinical impact of this infection seems to be negligible.
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spelling pubmed-81605982021-06-02 Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study Stadnik, Claudio Marcel B Caurio, Cassia Ferreira B Rodrigues-Filho, Edison M Nedel, Wagner L Cantisani, Guido PC Zanotelli, Maria L Pasqualotto, Alessandro C World J Gastrointest Pathophysiol Prospective Study BACKGROUND: Cytomegalovirus (CMV) is the most common viral pathogen after liver transplantation (LT). Although reactivation of CMV infection is generally described in the context of immunosuppression, it has also been described in critically ill immunocompetent patients including cirrhotic patients. AIM: To determine the incidence of reactivated CMV prior to LT. METHODS: This was a prospective cohort study evaluating adult patients who underwent LT between 2014 and 2016. A plasma sample was obtained from all patients for CMV quantitative real-time PCR testing right before transplantation. Patients were followed for at least 1 year to assess the following outcomes: Incidence of CMV infection, organ rejection and overall mortality. RESULTS: A total of 72 patients were enrolled. Four patients died before transplantation, thus 68 patients were followed up for a median of 44 mo (20-50 mo). In 23/72 patients (31.9%) CMV was reactivated before transplantation. Post-transplantation, 16/68 (23.5%) patients had CMV infection and that was significantly associated with the recipient being CMV negative and a CMV-positive donor. Pre-transplant CMV reactivation was not associated with overall mortality (log rank: 0.9). CONCLUSION: This study shows that CMV infection is common in patients with chronic liver disease just before LT, but the clinical impact of this infection seems to be negligible. Baishideng Publishing Group Inc 2021-05-22 2021-05-22 /pmc/articles/PMC8160598/ /pubmed/34084592 http://dx.doi.org/10.4291/wjgp.v12.i3.51 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Prospective Study
Stadnik, Claudio Marcel B
Caurio, Cassia Ferreira B
Rodrigues-Filho, Edison M
Nedel, Wagner L
Cantisani, Guido PC
Zanotelli, Maria L
Pasqualotto, Alessandro C
Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title_full Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title_fullStr Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title_full_unstemmed Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title_short Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study
title_sort impact of cytomegalovirus reactivation just before liver transplantation: a prospective cohort study
topic Prospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160598/
https://www.ncbi.nlm.nih.gov/pubmed/34084592
http://dx.doi.org/10.4291/wjgp.v12.i3.51
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