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Knockout of the CMP–Sialic Acid Transporter SLC35A1 in Human Cell Lines Increases Transduction Efficiency of Adeno-Associated Virus 9: Implications for Gene Therapy Potency Assays

Recombinant adeno-associated viruses (AAV) have emerged as an important tool for gene therapy for human diseases. A prerequisite for clinical approval is an in vitro potency assay that can measure the transduction efficiency of each virus lot produced. The AAV serotypes are typical for gene therapy...

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Detalles Bibliográficos
Autores principales:	Banning, Antje, Zakrzewicz, Anna, Chen, Xin, Gray, Steven J., Tikkanen, Ritva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160606/ https://www.ncbi.nlm.nih.gov/pubmed/34069698 http://dx.doi.org/10.3390/cells10051259

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