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Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects

The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor. Although cefaclor belongs to the cephalosporin family antibiotic that has b...

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Autores principales: Jeong, Seung-Hyun, Jang, Ji-Hun, Cho, Hea-Young, Lee, Yong-Bok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160640/
https://www.ncbi.nlm.nih.gov/pubmed/34069627
http://dx.doi.org/10.3390/pharmaceutics13050754
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author Jeong, Seung-Hyun
Jang, Ji-Hun
Cho, Hea-Young
Lee, Yong-Bok
author_facet Jeong, Seung-Hyun
Jang, Ji-Hun
Cho, Hea-Young
Lee, Yong-Bok
author_sort Jeong, Seung-Hyun
collection PubMed
description The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor. Although cefaclor belongs to the cephalosporin family antibiotic that has been used in various indications, there have been very few population studies on factors affecting its pharmacokinetics. Therefore, this study is very important in that effective therapy could be possible through a population pharmacokinetic study that explores effective covariates related to cefaclor pharmacokinetic diversity between individuals. Pharmacokinetic results of 48 subjects with physical and biochemical parameters were used for the population pharmacokinetic analysis of cefaclor. A one-compartment with lag-time and first-order absorption/elimination was constructed as a base model and extended to include covariates that could influence between-subject variability. Creatinine clearance and body weight significantly influenced systemic clearance and distribution volume of cefaclor. Cefaclor’s final population pharmacokinetic model was validated and some of the population’s pharmacokinetic diversity could be explained. Herein, we first describe the establishment of a population pharmacokinetic model of cefaclor for healthy Koreans that might be useful for customizing cefaclor or exploring additional covariates in patients.
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spelling pubmed-81606402021-05-29 Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects Jeong, Seung-Hyun Jang, Ji-Hun Cho, Hea-Young Lee, Yong-Bok Pharmaceutics Article The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor. Although cefaclor belongs to the cephalosporin family antibiotic that has been used in various indications, there have been very few population studies on factors affecting its pharmacokinetics. Therefore, this study is very important in that effective therapy could be possible through a population pharmacokinetic study that explores effective covariates related to cefaclor pharmacokinetic diversity between individuals. Pharmacokinetic results of 48 subjects with physical and biochemical parameters were used for the population pharmacokinetic analysis of cefaclor. A one-compartment with lag-time and first-order absorption/elimination was constructed as a base model and extended to include covariates that could influence between-subject variability. Creatinine clearance and body weight significantly influenced systemic clearance and distribution volume of cefaclor. Cefaclor’s final population pharmacokinetic model was validated and some of the population’s pharmacokinetic diversity could be explained. Herein, we first describe the establishment of a population pharmacokinetic model of cefaclor for healthy Koreans that might be useful for customizing cefaclor or exploring additional covariates in patients. MDPI 2021-05-19 /pmc/articles/PMC8160640/ /pubmed/34069627 http://dx.doi.org/10.3390/pharmaceutics13050754 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeong, Seung-Hyun
Jang, Ji-Hun
Cho, Hea-Young
Lee, Yong-Bok
Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title_full Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title_fullStr Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title_full_unstemmed Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title_short Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
title_sort population pharmacokinetic analysis of cefaclor in healthy korean subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160640/
https://www.ncbi.nlm.nih.gov/pubmed/34069627
http://dx.doi.org/10.3390/pharmaceutics13050754
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