Cargando…

KRAS and EGFR Mutations Differentially Alter ABC Drug Transporter Expression in Cisplatin-Resistant Non-Small Cell Lung Cancer

Lung carcinoma is still the most common malignancy worldwide. One of the major subtypes of non-small cell lung cancer (NSCLC) is adenocarcinoma (AC). As driver mutations and hence therapies differ in AC subtypes, we theorized that the expression and function of ABC drug transporters important in mul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaromi, Luca, Csongei, Veronika, Vesel, Monika, Abdelwahab, ElHusseiny Mohamed Mahmud, Soltani, Amina, Torok, Zsofia, Smuk, Gabor, Sarosi, Veronika, Pongracz, Judit Erzsebet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160643/ https://www.ncbi.nlm.nih.gov/pubmed/34065402 http://dx.doi.org/10.3390/ijms22105384

Ejemplares similares

Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner
por: Kiss, Edit, et al.
Publicado: (2020)

Feasibility study of in vitro drug sensitivity assay of advanced non-small cell lung adenocarcinomas
por: Papp, Emoke, et al.
Publicado: (2020)

Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells
por: Abdelwahab, Elhusseiny Mohamed Mahmud, et al.
Publicado: (2019)

Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence
por: Kovacs, Tamas, et al.
Publicado: (2014)

Is an Immunosuppressive Microenvironment a Characteristic of Both Intra- and Extraparenchymal Central Nervous Tumors?
por: Soltani, Amina, et al.
Publicado: (2021)

Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited
por: Abdelwahab, ElHusseiny M. M., et al.
Publicado: (2021)

Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
por: Bovari-Biri, Judit, et al.
Publicado: (2023)

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations
por: Abdelwahab, Elhusseiny Mohamed Mahmoud, et al.
Publicado: (2021)

ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling
por: Vesel, M., et al.
Publicado: (2017)

miRNAs as Predictors of Barrier Integrity
por: Bovari-Biri, Judit, et al.
Publicado: (2023)

Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence
por: Varecza, Zoltan, et al.
Publicado: (2011)

Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines
por: Feller, Diana, et al.
Publicado: (2018)

WNT signaling – lung cancer is no exception
por: Rapp, Judit, et al.
Publicado: (2017)

GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?
por: Mohás, Márton, et al.
Publicado: (2010)

IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis
por: Fischer, Sarah, et al.
Publicado: (2017)

EGFR T790M Mutation Detection in Patients With Non-Small Cell Lung Cancer After First Line EGFR TKI Therapy: Summary of Results in a Three-Year Period and a Comparison of Commercially Available Detection Kits
por: Bencze, Eszter, et al.
Publicado: (2022)

Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility
por: Rapp, J., et al.
Publicado: (2016)

Down-Regulation of Canonical and Up-Regulation of Non-Canonical Wnt Signalling in the Carcinogenic Process of Squamous Cell Lung Carcinoma
por: Bartis, Domokos, et al.
Publicado: (2013)

The effects of bisphosphonate and radiation therapy in bone-metastatic lung adenocarcinoma: the impact of KRAS mutation
por: Radeczky, Peter, et al.
Publicado: (2021)

Erlotinib as single agent first line treatment in locally advanced or metastatic activating EGFR mutation-positive lung adenocarcinoma (CEETAC): an open-label, non-randomized, multicenter, phase IV clinical trial
por: Markóczy, Zsolt, et al.
Publicado: (2018)

KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis
por: Lohinai, Zoltan, et al.
Publicado: (2017)

Unfolding Individual Domains of BmrA, a Bacterial ABC Transporter Involved in Multidrug Resistance
por: Oepen, Kristin, et al.
Publicado: (2023)

Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target
por: Abdelwahab, E. M. M., et al.
Publicado: (2018)

Improvement in Lung Cancer Survival: 6-Year Trends of Overall Survival at Hungarian Patients Diagnosed in 2011–2016
por: Bogos, Krisztina, et al.
Publicado: (2021)

The efficacy and safety of bevacizumab in addition to platinum-based chemotherapy for the first-line treatment of patients with advanced nonsquamous non-small-cell lung cancer: Final results of AVALANCHE, an observational cohort study
por: Tolnay, Edina, et al.
Publicado: (2019)

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer
por: Vrana, David, et al.
Publicado: (2018)

A comparability study of 5 commercial KRAS tests
por: Oliner, Kelly, et al.
Publicado: (2010)

Increase in the Length of Lung Cancer Patient Pathway Before First-Line Therapy: A 6-Year Nationwide Analysis From Hungary
por: Kiss, Zoltan, et al.
Publicado: (2021)

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome
por: Lemstrova, Radmila, et al.
Publicado: (2017)

Revising Incidence and Mortality of Lung Cancer in Central Europe: An Epidemiology Review From Hungary
por: Bogos, Krisztina, et al.
Publicado: (2019)

Comparison of the algorithms classifying the ABC and GCB subtypes in diffuse large B-cell lymphoma
por: Boltežar, Lučka, et al.
Publicado: (2018)

Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response
por: Hlaváč, Viktor, et al.
Publicado: (2020)

Spinal Aneurysmal Bone Cysts (ABCs): Optimal Management
por: Parker, Jack, et al.
Publicado: (2019)

Impact of Clinical Factors on Generic and Disease-Specific Quality of Life in COPD and Asthma-COPD Overlap with Exacerbations
por: Lázár, Zsófia, et al.
Publicado: (2020)

Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System
por: Hohenforst-Schmidt, Wolfgang, et al.
Publicado: (2014)

Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016
por: Tamási, Lilla, et al.
Publicado: (2021)

CRISPR-Induced Loss of Connexin 43 Expression Sensitizes KRAS Mutant Cells to Cisplatin
por: Martin, Stephen, et al.
Publicado: (2022)

The volume of the black hole interior at late times
por: Sarosi, Gabor
Publicado: (2021)

EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma
por: Chalela, Roberto, et al.
Publicado: (2021)

Comprehensive Collection and Prediction of ABC Transmembrane Protein Structures in the AI Era of Structural Biology
por: Tordai, Hedvig, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7363shqbtglv5cjp4nh2ggrng6