Cargando…

Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma

SIMPLE SUMMARY: High recurrence rates after resection of liver cancer (hepatocellular carcinoma) with curative intent impair clinical outcomes of patients diagnosed with liver cancer. Cancer/testis antigens (CTAs) are expressed in cancer and can serve as therapeutic targets. We identified 12 CTAs ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noordam, Lisanne, Ge, Zhouhong, Özturk, Hadiye, Doukas, Michail, Mancham, Shanta, Boor, Patrick P. C., Campos Carrascosa, Lucia, Zhou, Guoying, van den Bosch, Thierry P. P., Pan, Qiuwei, IJzermans, Jan N. M., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160719/ https://www.ncbi.nlm.nih.gov/pubmed/34065388 http://dx.doi.org/10.3390/cancers13102499

Ejemplares similares

GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma
por: van Beek, Adriaan A., et al.
Publicado: (2019)

Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients
por: Noordam, Lisanne, et al.
Publicado: (2022)

TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma
por: Ge, Zhouhong, et al.
Publicado: (2021)

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer
por: Zhou, Guoying, et al.
Publicado: (2018)

Detection of oncogenic mutations in paired circulating tumor DNA and circulating tumor cells in patients with hepatocellular carcinoma
por: Ge, Zhouhong, et al.
Publicado: (2021)

TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer
por: Ge, Zhouhong, et al.
Publicado: (2021)

Activated CD4(+) T Cells and Highly Differentiated Alloreactive CD4(+) T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients
por: Duizendstra, Aafke A., et al.
Publicado: (2021)

Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance
por: Liu, Jiaye, et al.
Publicado: (2020)

FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells
por: Campos Carrascosa, Lucia, et al.
Publicado: (2020)

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma
por: Rakké, Yannick Sebastiaan, et al.
Publicado: (2020)

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis
por: Boor, Patrick P. C., et al.
Publicado: (2020)

Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels
por: Sideras, Kostandinos, et al.
Publicado: (2019)

PD-L1, Galectin-9 and CD8(+) tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma
por: Sideras, Kostandinos, et al.
Publicado: (2017)

Prognostic value of intra‐tumoral CD8(+)/FoxP3(+) lymphocyte ratio in patients with resected colorectal cancer liver metastasis
por: Sideras, Kostandinos, et al.
Publicado: (2018)

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
por: Zhou, Guoying, et al.
Publicado: (2022)

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
por: Pedroza-Gonzalez, Alexander, et al.
Publicado: (2013)

LGR5 marks targetable tumor-initiating cells in mouse liver cancer
por: Cao, Wanlu, et al.
Publicado: (2020)

Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma
por: Ma, Buyun, et al.
Publicado: (2018)

Cancer Cell B7-H3 Expression Is More Prevalent in the Pancreato-Biliary Subtype of Ampullary Cancer Than in Pancreatic Cancer
por: Geerdes, Emma E., et al.
Publicado: (2021)

Detailed Kinetics of the Direct Allo-Response in Human Liver Transplant Recipients: New Insights from an Optimized Assay
por: Tapirdamaz, Özlem, et al.
Publicado: (2010)

GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
por: Rakké, Yannick S., et al.
Publicado: (2022)

Current Tolerance-Associated Peripheral Blood Gene Expression Profiles After Liver Transplantation Are Influenced by Immunosuppressive Drugs and Prior Cytomegalovirus Infection
por: Duizendstra, Aafke A., et al.
Publicado: (2022)

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
por: Li, Meng, et al.
Publicado: (2020)

External Validation of the RETREAT Score for Prediction of Hepatocellular Carcinoma Recurrence after Liver Transplantation
por: van Hooff, Maria C., et al.
Publicado: (2022)

Characterization of Antigen-Presenting Cell Subsets in Human Liver-Draining Lymph Nodes
por: Boor, Patrick P. C., et al.
Publicado: (2019)

Distinguishing epigenetic features of preneoplastic testis tissues adjacent to seminomas and nonseminomas
por: Gainetdinov, Ildar V., et al.
Publicado: (2016)

Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis
por: Höppener, Diederik J., et al.
Publicado: (2020)

The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer
por: Zhang, Ruyi, et al.
Publicado: (2020)

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma
por: Li, Juan, et al.
Publicado: (2017)

Intraosseous epidermoid cysts of adjacent digits in a dog
por: Vagias, Michail, et al.
Publicado: (2020)

Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area
por: Sideras, K, et al.
Publicado: (2015)

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling()
por: Wang, Wenhui, et al.
Publicado: (2016)

Transcriptomic Analysis of Livers of Inactive Carriers of Hepatitis B Virus With Distinct Expression of Hepatitis B Surface Antigen
por: Rico Montanari, Noe, et al.
Publicado: (2021)

Down-Regulation of Collagen Hydroxylation in Colorectal Liver Metastasis
por: van Huizen, Nick A., et al.
Publicado: (2020)

A multi‐regional, hierarchical‐tier mathematical model of the spread and control of COVID‐19 epidemics from epicentre to adjacent regions
por: Zheng, Qinyue, et al.
Publicado: (2021)

Phenotype or Genotype: Decision‐Making Dilemmas in Hepatocellular Adenoma
por: Klompenhouwer, Anne J., et al.
Publicado: (2019)

Immunopeptidome of hepatocytes isolated from patients with HBV infection and hepatocellular carcinoma
por: de Beijer, Monique T.A., et al.
Publicado: (2022)

Drugs and the blood-testis barrier
por: Setchell, B. P., et al.
Publicado: (1978)

Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing
por: Pan, Qiuwei, et al.
Publicado: (2009)

Reply to: Comment on ‘Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area'
por: Sideras, Kostandinos, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8dkv40el6co8q9qfr4ivdddh96