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Extracellular Vesicles from Plants: Current Knowledge and Open Questions

The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and bi...

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Detalles Bibliográficos
Autores principales: Urzì, Ornella, Raimondo, Stefania, Alessandro, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160738/
https://www.ncbi.nlm.nih.gov/pubmed/34065193
http://dx.doi.org/10.3390/ijms22105366
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author Urzì, Ornella
Raimondo, Stefania
Alessandro, Riccardo
author_facet Urzì, Ornella
Raimondo, Stefania
Alessandro, Riccardo
author_sort Urzì, Ornella
collection PubMed
description The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs in terms of isolation, characterization of their content, biological properties, and potential use as drug delivery systems. In conclusion, we outline controversial issues on which the scientific community shall focus the attention shortly.
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spelling pubmed-81607382021-05-29 Extracellular Vesicles from Plants: Current Knowledge and Open Questions Urzì, Ornella Raimondo, Stefania Alessandro, Riccardo Int J Mol Sci Review The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs in terms of isolation, characterization of their content, biological properties, and potential use as drug delivery systems. In conclusion, we outline controversial issues on which the scientific community shall focus the attention shortly. MDPI 2021-05-20 /pmc/articles/PMC8160738/ /pubmed/34065193 http://dx.doi.org/10.3390/ijms22105366 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Urzì, Ornella
Raimondo, Stefania
Alessandro, Riccardo
Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title_full Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title_fullStr Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title_full_unstemmed Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title_short Extracellular Vesicles from Plants: Current Knowledge and Open Questions
title_sort extracellular vesicles from plants: current knowledge and open questions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160738/
https://www.ncbi.nlm.nih.gov/pubmed/34065193
http://dx.doi.org/10.3390/ijms22105366
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