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Extracellular Vesicles from Plants: Current Knowledge and Open Questions
The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and bi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160738/ https://www.ncbi.nlm.nih.gov/pubmed/34065193 http://dx.doi.org/10.3390/ijms22105366 |
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author | Urzì, Ornella Raimondo, Stefania Alessandro, Riccardo |
author_facet | Urzì, Ornella Raimondo, Stefania Alessandro, Riccardo |
author_sort | Urzì, Ornella |
collection | PubMed |
description | The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs in terms of isolation, characterization of their content, biological properties, and potential use as drug delivery systems. In conclusion, we outline controversial issues on which the scientific community shall focus the attention shortly. |
format | Online Article Text |
id | pubmed-8160738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81607382021-05-29 Extracellular Vesicles from Plants: Current Knowledge and Open Questions Urzì, Ornella Raimondo, Stefania Alessandro, Riccardo Int J Mol Sci Review The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs in terms of isolation, characterization of their content, biological properties, and potential use as drug delivery systems. In conclusion, we outline controversial issues on which the scientific community shall focus the attention shortly. MDPI 2021-05-20 /pmc/articles/PMC8160738/ /pubmed/34065193 http://dx.doi.org/10.3390/ijms22105366 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Urzì, Ornella Raimondo, Stefania Alessandro, Riccardo Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title | Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title_full | Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title_fullStr | Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title_full_unstemmed | Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title_short | Extracellular Vesicles from Plants: Current Knowledge and Open Questions |
title_sort | extracellular vesicles from plants: current knowledge and open questions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160738/ https://www.ncbi.nlm.nih.gov/pubmed/34065193 http://dx.doi.org/10.3390/ijms22105366 |
work_keys_str_mv | AT urziornella extracellularvesiclesfromplantscurrentknowledgeandopenquestions AT raimondostefania extracellularvesiclesfromplantscurrentknowledgeandopenquestions AT alessandroriccardo extracellularvesiclesfromplantscurrentknowledgeandopenquestions |