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Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology
Parkinson’s disease medication treatment planning is generally based on subjective data obtained through clinical, physician-patient interactions. The Personal KinetiGraph™ (PKG) and similar wearable sensors have shown promise in enabling objective, continuous remote health monitoring for Parkinson’...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160757/ https://www.ncbi.nlm.nih.gov/pubmed/34065245 http://dx.doi.org/10.3390/s21103553 |
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author | Watts, Jeremy Khojandi, Anahita Vasudevan, Rama Nahab, Fatta B. Ramdhani, Ritesh A. |
author_facet | Watts, Jeremy Khojandi, Anahita Vasudevan, Rama Nahab, Fatta B. Ramdhani, Ritesh A. |
author_sort | Watts, Jeremy |
collection | PubMed |
description | Parkinson’s disease medication treatment planning is generally based on subjective data obtained through clinical, physician-patient interactions. The Personal KinetiGraph™ (PKG) and similar wearable sensors have shown promise in enabling objective, continuous remote health monitoring for Parkinson’s patients. In this proof-of-concept study, we propose to use objective sensor data from the PKG and apply machine learning to cluster patients based on levodopa regimens and response. The resulting clusters are then used to enhance treatment planning by providing improved initial treatment estimates to supplement a physician’s initial assessment. We apply k-means clustering to a dataset of within-subject Parkinson’s medication changes—clinically assessed by the MDS-Unified Parkinson’s Disease Rating Scale-III (MDS-UPDRS-III) and the PKG sensor for movement staging. A random forest classification model was then used to predict patients’ cluster allocation based on their respective demographic information, MDS-UPDRS-III scores, and PKG time-series data. Clinically relevant clusters were partitioned by levodopa dose, medication administration frequency, and total levodopa equivalent daily dose—with the PKG providing similar symptomatic assessments to physician MDS-UPDRS-III scores. A random forest classifier trained on demographic information, MDS-UPDRS-III scores, and PKG time-series data was able to accurately classify subjects of the two most demographically similar clusters with an accuracy of 86.9%, an F1 score of 90.7%, and an AUC of 0.871. A model that relied solely on demographic information and PKG time-series data provided the next best performance with an accuracy of 83.8%, an F1 score of 88.5%, and an AUC of 0.831, hence further enabling fully remote assessments. These computational methods demonstrate the feasibility of using sensor-based data to cluster patients based on their medication responses with further potential to assist with medication recommendations. |
format | Online Article Text |
id | pubmed-8160757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81607572021-05-29 Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology Watts, Jeremy Khojandi, Anahita Vasudevan, Rama Nahab, Fatta B. Ramdhani, Ritesh A. Sensors (Basel) Article Parkinson’s disease medication treatment planning is generally based on subjective data obtained through clinical, physician-patient interactions. The Personal KinetiGraph™ (PKG) and similar wearable sensors have shown promise in enabling objective, continuous remote health monitoring for Parkinson’s patients. In this proof-of-concept study, we propose to use objective sensor data from the PKG and apply machine learning to cluster patients based on levodopa regimens and response. The resulting clusters are then used to enhance treatment planning by providing improved initial treatment estimates to supplement a physician’s initial assessment. We apply k-means clustering to a dataset of within-subject Parkinson’s medication changes—clinically assessed by the MDS-Unified Parkinson’s Disease Rating Scale-III (MDS-UPDRS-III) and the PKG sensor for movement staging. A random forest classification model was then used to predict patients’ cluster allocation based on their respective demographic information, MDS-UPDRS-III scores, and PKG time-series data. Clinically relevant clusters were partitioned by levodopa dose, medication administration frequency, and total levodopa equivalent daily dose—with the PKG providing similar symptomatic assessments to physician MDS-UPDRS-III scores. A random forest classifier trained on demographic information, MDS-UPDRS-III scores, and PKG time-series data was able to accurately classify subjects of the two most demographically similar clusters with an accuracy of 86.9%, an F1 score of 90.7%, and an AUC of 0.871. A model that relied solely on demographic information and PKG time-series data provided the next best performance with an accuracy of 83.8%, an F1 score of 88.5%, and an AUC of 0.831, hence further enabling fully remote assessments. These computational methods demonstrate the feasibility of using sensor-based data to cluster patients based on their medication responses with further potential to assist with medication recommendations. MDPI 2021-05-20 /pmc/articles/PMC8160757/ /pubmed/34065245 http://dx.doi.org/10.3390/s21103553 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Watts, Jeremy Khojandi, Anahita Vasudevan, Rama Nahab, Fatta B. Ramdhani, Ritesh A. Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title | Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title_full | Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title_fullStr | Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title_full_unstemmed | Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title_short | Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology |
title_sort | improving medication regimen recommendation for parkinson’s disease using sensor technology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160757/ https://www.ncbi.nlm.nih.gov/pubmed/34065245 http://dx.doi.org/10.3390/s21103553 |
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