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Glia and Orofacial Pain: Progress and Future Directions

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells an...

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Autores principales: Ye, Yi, Salvo, Elizabeth, Romero-Reyes, Marcela, Akerman, Simon, Shimizu, Emi, Kobayashi, Yoshifumi, Michot, Benoit, Gibbs, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160907/
https://www.ncbi.nlm.nih.gov/pubmed/34069553
http://dx.doi.org/10.3390/ijms22105345
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author Ye, Yi
Salvo, Elizabeth
Romero-Reyes, Marcela
Akerman, Simon
Shimizu, Emi
Kobayashi, Yoshifumi
Michot, Benoit
Gibbs, Jennifer
author_facet Ye, Yi
Salvo, Elizabeth
Romero-Reyes, Marcela
Akerman, Simon
Shimizu, Emi
Kobayashi, Yoshifumi
Michot, Benoit
Gibbs, Jennifer
author_sort Ye, Yi
collection PubMed
description Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions.
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spelling pubmed-81609072021-05-29 Glia and Orofacial Pain: Progress and Future Directions Ye, Yi Salvo, Elizabeth Romero-Reyes, Marcela Akerman, Simon Shimizu, Emi Kobayashi, Yoshifumi Michot, Benoit Gibbs, Jennifer Int J Mol Sci Review Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions. MDPI 2021-05-19 /pmc/articles/PMC8160907/ /pubmed/34069553 http://dx.doi.org/10.3390/ijms22105345 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ye, Yi
Salvo, Elizabeth
Romero-Reyes, Marcela
Akerman, Simon
Shimizu, Emi
Kobayashi, Yoshifumi
Michot, Benoit
Gibbs, Jennifer
Glia and Orofacial Pain: Progress and Future Directions
title Glia and Orofacial Pain: Progress and Future Directions
title_full Glia and Orofacial Pain: Progress and Future Directions
title_fullStr Glia and Orofacial Pain: Progress and Future Directions
title_full_unstemmed Glia and Orofacial Pain: Progress and Future Directions
title_short Glia and Orofacial Pain: Progress and Future Directions
title_sort glia and orofacial pain: progress and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160907/
https://www.ncbi.nlm.nih.gov/pubmed/34069553
http://dx.doi.org/10.3390/ijms22105345
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