Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors

Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse as...

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Autores principales: Prill, Monika, Karkucinska-Wieckowska, Agnieszka, Lebiedzinska-Arciszewska, Magdalena, Morciano, Giampaolo, Charzynska, Agata, Dabrowski, Michal, Pronicki, Maciej, Pinton, Paolo, Grajkowska, Wieslawa, Wieckowski, Mariusz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160917/
https://www.ncbi.nlm.nih.gov/pubmed/34065573
http://dx.doi.org/10.3390/jcm10102219
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author Prill, Monika
Karkucinska-Wieckowska, Agnieszka
Lebiedzinska-Arciszewska, Magdalena
Morciano, Giampaolo
Charzynska, Agata
Dabrowski, Michal
Pronicki, Maciej
Pinton, Paolo
Grajkowska, Wieslawa
Wieckowski, Mariusz R.
author_facet Prill, Monika
Karkucinska-Wieckowska, Agnieszka
Lebiedzinska-Arciszewska, Magdalena
Morciano, Giampaolo
Charzynska, Agata
Dabrowski, Michal
Pronicki, Maciej
Pinton, Paolo
Grajkowska, Wieslawa
Wieckowski, Mariusz R.
author_sort Prill, Monika
collection PubMed
description Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins.
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spelling pubmed-81609172021-05-29 Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors Prill, Monika Karkucinska-Wieckowska, Agnieszka Lebiedzinska-Arciszewska, Magdalena Morciano, Giampaolo Charzynska, Agata Dabrowski, Michal Pronicki, Maciej Pinton, Paolo Grajkowska, Wieslawa Wieckowski, Mariusz R. J Clin Med Article Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins. MDPI 2021-05-20 /pmc/articles/PMC8160917/ /pubmed/34065573 http://dx.doi.org/10.3390/jcm10102219 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prill, Monika
Karkucinska-Wieckowska, Agnieszka
Lebiedzinska-Arciszewska, Magdalena
Morciano, Giampaolo
Charzynska, Agata
Dabrowski, Michal
Pronicki, Maciej
Pinton, Paolo
Grajkowska, Wieslawa
Wieckowski, Mariusz R.
Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title_full Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title_fullStr Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title_full_unstemmed Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title_short Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
title_sort ras, trkb, and shca protein expression patterns in pediatric brain tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160917/
https://www.ncbi.nlm.nih.gov/pubmed/34065573
http://dx.doi.org/10.3390/jcm10102219
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