The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mecha...

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Detalles Bibliográficos
Autores principales: Figurek, Andreja, Rroji, Merita, Spasovski, Goce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161087/
https://www.ncbi.nlm.nih.gov/pubmed/34065339
http://dx.doi.org/10.3390/cells10051266
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author Figurek, Andreja
Rroji, Merita
Spasovski, Goce
author_facet Figurek, Andreja
Rroji, Merita
Spasovski, Goce
author_sort Figurek, Andreja
collection PubMed
description Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.
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spelling pubmed-81610872021-05-29 The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu Figurek, Andreja Rroji, Merita Spasovski, Goce Cells Review Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed. MDPI 2021-05-20 /pmc/articles/PMC8161087/ /pubmed/34065339 http://dx.doi.org/10.3390/cells10051266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Figurek, Andreja
Rroji, Merita
Spasovski, Goce
The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title_full The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title_fullStr The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title_full_unstemmed The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title_short The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
title_sort complexity of fgf23 effects on cardiomyocytes in normal and uremic milieu
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161087/
https://www.ncbi.nlm.nih.gov/pubmed/34065339
http://dx.doi.org/10.3390/cells10051266
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