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Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry

(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up f...

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Autores principales: Rubio-Rivas, Manuel, Corbella, Xavier, Formiga, Francesc, Menéndez Fernández, Estela, Martín Escalante, María Dolores, Baños Fernández, Isolina, Arnalich Fernández, Francisco, Del Corral-Beamonte, Esther, Lalueza, Antonio, Parra Virto, Alejandro, Roy Vallejo, Emilia, Loureiro-Amigo, José, Álvarez Suárez, Ana María, Abadía-Otero, Jesica, Navarro De La Chica, María, Estévez González, Raquel, Hernández Milián, Almudena, Areses Manrique, María, Blázquez Encinar, Julio César, González Noya, Amara, González Ferrer, Ruth, Pérez Aguilera, María, Gil Sánchez, Ricardo, Millán Núñez-Cortés, Jesús, Casas-Rojo, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161115/
https://www.ncbi.nlm.nih.gov/pubmed/34065316
http://dx.doi.org/10.3390/jcm10102214
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author Rubio-Rivas, Manuel
Corbella, Xavier
Formiga, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Del Corral-Beamonte, Esther
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro-Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro De La Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas-Rojo, José Manuel
author_facet Rubio-Rivas, Manuel
Corbella, Xavier
Formiga, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Del Corral-Beamonte, Esther
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro-Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro De La Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas-Rojo, José Manuel
author_sort Rubio-Rivas, Manuel
collection PubMed
description (1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. (4) Conclusion: The present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.
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spelling pubmed-81611152021-05-29 Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry Rubio-Rivas, Manuel Corbella, Xavier Formiga, Francesc Menéndez Fernández, Estela Martín Escalante, María Dolores Baños Fernández, Isolina Arnalich Fernández, Francisco Del Corral-Beamonte, Esther Lalueza, Antonio Parra Virto, Alejandro Roy Vallejo, Emilia Loureiro-Amigo, José Álvarez Suárez, Ana María Abadía-Otero, Jesica Navarro De La Chica, María Estévez González, Raquel Hernández Milián, Almudena Areses Manrique, María Blázquez Encinar, Julio César González Noya, Amara González Ferrer, Ruth Pérez Aguilera, María Gil Sánchez, Ricardo Millán Núñez-Cortés, Jesús Casas-Rojo, José Manuel J Clin Med Article (1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. (4) Conclusion: The present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters. MDPI 2021-05-20 /pmc/articles/PMC8161115/ /pubmed/34065316 http://dx.doi.org/10.3390/jcm10102214 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rubio-Rivas, Manuel
Corbella, Xavier
Formiga, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Del Corral-Beamonte, Esther
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro-Amigo, José
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro De La Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas-Rojo, José Manuel
Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title_full Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title_fullStr Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title_full_unstemmed Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title_short Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry
title_sort risk categories in covid-19 based on degrees of inflammation: data on more than 17,000 patients from the spanish semi-covid-19 registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161115/
https://www.ncbi.nlm.nih.gov/pubmed/34065316
http://dx.doi.org/10.3390/jcm10102214
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