Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib

The emergence of secondary resistance is the main failure cause of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) as a targeted therapy for non-small cell lung cancer (NSCLC). EGFR mutations of NSCLC cells can markedly increase glutamine transporter (SLC1A5) expression, ther...

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Detalles Bibliográficos
Autores principales: Liu, Yaming, Ge, Xianming, Pang, Jinlong, Zhang, Yuhan, Zhang, Hao, Wu, Hongyan, Fan, Fangtian, Liu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161200/
https://www.ncbi.nlm.nih.gov/pubmed/34054543
http://dx.doi.org/10.3389/fphar.2021.671328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161200/
https://www.ncbi.nlm.nih.gov/pubmed/34054543
http://dx.doi.org/10.3389/fphar.2021.671328

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