Tau Exon 10 Inclusion by PrP(C) through Downregulating GSK3β Activity

Tau protein is largely responsible for tauopathies, including Alzheimer’s disease (AD), where it accumulates in the brain as insoluble aggregates. Tau mRNA is regulated by alternative splicing, and inclusion or exclusion of exon 10 gives rise to the 3R and 4R isoforms respectively, whose balance is...

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Detalles Bibliográficos
Autores principales: Lidón, Laia, Llaó-Hierro, Laura, Nuvolone, Mario, Aguzzi, Adriano, Ávila, Jesús, Ferrer, Isidro, del Río, José Antonio, Gavín, Rosalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161268/
https://www.ncbi.nlm.nih.gov/pubmed/34065232
http://dx.doi.org/10.3390/ijms22105370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161268/
https://www.ncbi.nlm.nih.gov/pubmed/34065232
http://dx.doi.org/10.3390/ijms22105370

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