Cargando…
The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configurati...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161275/ https://www.ncbi.nlm.nih.gov/pubmed/34065414 http://dx.doi.org/10.3390/pharmaceutics13050759 |
_version_ | 1783700471948509184 |
---|---|
author | Melocchi, Alice Uboldi, Marco Briatico-Vangosa, Francesco Moutaharrik, Saliha Cerea, Matteo Foppoli, Anastasia Maroni, Alessandra Palugan, Luca Zema, Lucia Gazzaniga, Andrea |
author_facet | Melocchi, Alice Uboldi, Marco Briatico-Vangosa, Francesco Moutaharrik, Saliha Cerea, Matteo Foppoli, Anastasia Maroni, Alessandra Palugan, Luca Zema, Lucia Gazzaniga, Andrea |
author_sort | Melocchi, Alice |
collection | PubMed |
description | The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one. |
format | Online Article Text |
id | pubmed-8161275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81612752021-05-29 The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) Melocchi, Alice Uboldi, Marco Briatico-Vangosa, Francesco Moutaharrik, Saliha Cerea, Matteo Foppoli, Anastasia Maroni, Alessandra Palugan, Luca Zema, Lucia Gazzaniga, Andrea Pharmaceutics Article The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one. MDPI 2021-05-20 /pmc/articles/PMC8161275/ /pubmed/34065414 http://dx.doi.org/10.3390/pharmaceutics13050759 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Melocchi, Alice Uboldi, Marco Briatico-Vangosa, Francesco Moutaharrik, Saliha Cerea, Matteo Foppoli, Anastasia Maroni, Alessandra Palugan, Luca Zema, Lucia Gazzaniga, Andrea The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title | The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title_full | The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title_fullStr | The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title_full_unstemmed | The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title_short | The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM) |
title_sort | chronotopic™ system for pulsatile and colonic delivery of active molecules in the era of precision medicine: feasibility by 3d printing via fused deposition modeling (fdm) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161275/ https://www.ncbi.nlm.nih.gov/pubmed/34065414 http://dx.doi.org/10.3390/pharmaceutics13050759 |
work_keys_str_mv | AT melocchialice thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT uboldimarco thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT briaticovangosafrancesco thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT moutaharriksaliha thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT cereamatteo thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT foppolianastasia thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT maronialessandra thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT paluganluca thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT zemalucia thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT gazzanigaandrea thechronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT melocchialice chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT uboldimarco chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT briaticovangosafrancesco chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT moutaharriksaliha chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT cereamatteo chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT foppolianastasia chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT maronialessandra chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT paluganluca chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT zemalucia chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm AT gazzanigaandrea chronotopicsystemforpulsatileandcolonicdeliveryofactivemoleculesintheeraofprecisionmedicinefeasibilityby3dprintingviafuseddepositionmodelingfdm |