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Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential

Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of diet...

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Autores principales: Hashimoto, Michio, Matsuzaki, Kentaro, Hossain, Shahdat, Ito, Tomoko, Wakatsuki, Harumi, Tanabe, Yoko, Ohno, Miho, Kato, Setsushi, Yamashita, Kazuya, Shido, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161281/
https://www.ncbi.nlm.nih.gov/pubmed/34069601
http://dx.doi.org/10.3390/foods10051130
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author Hashimoto, Michio
Matsuzaki, Kentaro
Hossain, Shahdat
Ito, Tomoko
Wakatsuki, Harumi
Tanabe, Yoko
Ohno, Miho
Kato, Setsushi
Yamashita, Kazuya
Shido, Osamu
author_facet Hashimoto, Michio
Matsuzaki, Kentaro
Hossain, Shahdat
Ito, Tomoko
Wakatsuki, Harumi
Tanabe, Yoko
Ohno, Miho
Kato, Setsushi
Yamashita, Kazuya
Shido, Osamu
author_sort Hashimoto, Michio
collection PubMed
description Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels.
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spelling pubmed-81612812021-05-29 Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential Hashimoto, Michio Matsuzaki, Kentaro Hossain, Shahdat Ito, Tomoko Wakatsuki, Harumi Tanabe, Yoko Ohno, Miho Kato, Setsushi Yamashita, Kazuya Shido, Osamu Foods Article Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels. MDPI 2021-05-19 /pmc/articles/PMC8161281/ /pubmed/34069601 http://dx.doi.org/10.3390/foods10051130 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hashimoto, Michio
Matsuzaki, Kentaro
Hossain, Shahdat
Ito, Tomoko
Wakatsuki, Harumi
Tanabe, Yoko
Ohno, Miho
Kato, Setsushi
Yamashita, Kazuya
Shido, Osamu
Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title_full Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title_fullStr Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title_full_unstemmed Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title_short Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
title_sort perilla seed oil enhances cognitive function and mental health in healthy elderly japanese individuals by enhancing the biological antioxidant potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161281/
https://www.ncbi.nlm.nih.gov/pubmed/34069601
http://dx.doi.org/10.3390/foods10051130
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