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Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential
Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of diet...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161281/ https://www.ncbi.nlm.nih.gov/pubmed/34069601 http://dx.doi.org/10.3390/foods10051130 |
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author | Hashimoto, Michio Matsuzaki, Kentaro Hossain, Shahdat Ito, Tomoko Wakatsuki, Harumi Tanabe, Yoko Ohno, Miho Kato, Setsushi Yamashita, Kazuya Shido, Osamu |
author_facet | Hashimoto, Michio Matsuzaki, Kentaro Hossain, Shahdat Ito, Tomoko Wakatsuki, Harumi Tanabe, Yoko Ohno, Miho Kato, Setsushi Yamashita, Kazuya Shido, Osamu |
author_sort | Hashimoto, Michio |
collection | PubMed |
description | Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels. |
format | Online Article Text |
id | pubmed-8161281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81612812021-05-29 Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential Hashimoto, Michio Matsuzaki, Kentaro Hossain, Shahdat Ito, Tomoko Wakatsuki, Harumi Tanabe, Yoko Ohno, Miho Kato, Setsushi Yamashita, Kazuya Shido, Osamu Foods Article Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels. MDPI 2021-05-19 /pmc/articles/PMC8161281/ /pubmed/34069601 http://dx.doi.org/10.3390/foods10051130 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hashimoto, Michio Matsuzaki, Kentaro Hossain, Shahdat Ito, Tomoko Wakatsuki, Harumi Tanabe, Yoko Ohno, Miho Kato, Setsushi Yamashita, Kazuya Shido, Osamu Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title | Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title_full | Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title_fullStr | Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title_full_unstemmed | Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title_short | Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential |
title_sort | perilla seed oil enhances cognitive function and mental health in healthy elderly japanese individuals by enhancing the biological antioxidant potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161281/ https://www.ncbi.nlm.nih.gov/pubmed/34069601 http://dx.doi.org/10.3390/foods10051130 |
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