A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse

Increasing evidence links metabolic disorders with neurodegenerative processes including Alzheimer’s disease (AD). Late AD is associated with amyloid (Aβ) plaque accumulation, neuroinflammation, and central insulin resistance. Here, a humanized AD model, the 5xFAD mouse model, was used to further ex...

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Detalles Bibliográficos
Autores principales: López-Gambero, Antonio J., Rosell-Valle, Cristina, Medina-Vera, Dina, Navarro, Juan Antonio, Vargas, Antonio, Rivera, Patricia, Sanjuan, Carlos, Rodríguez de Fonseca, Fernando, Suárez, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161294/
https://www.ncbi.nlm.nih.gov/pubmed/34065168
http://dx.doi.org/10.3390/ijms22105365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161294/
https://www.ncbi.nlm.nih.gov/pubmed/34065168
http://dx.doi.org/10.3390/ijms22105365

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