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Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus
Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the Sout...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161303/ https://www.ncbi.nlm.nih.gov/pubmed/34069724 http://dx.doi.org/10.3390/md19050281 |
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author | Peng, Gao-Yang Kurtán, Tibor Mándi, Attila He, Jing Cao, Zheng-Yu Tang, Hua Mao, Shui-Chun Zhang, Wen |
author_facet | Peng, Gao-Yang Kurtán, Tibor Mándi, Attila He, Jing Cao, Zheng-Yu Tang, Hua Mao, Shui-Chun Zhang, Wen |
author_sort | Peng, Gao-Yang |
collection | PubMed |
description | Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca(2+) oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure–activity relationship was discussed. |
format | Online Article Text |
id | pubmed-8161303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81613032021-05-29 Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus Peng, Gao-Yang Kurtán, Tibor Mándi, Attila He, Jing Cao, Zheng-Yu Tang, Hua Mao, Shui-Chun Zhang, Wen Mar Drugs Article Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca(2+) oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure–activity relationship was discussed. MDPI 2021-05-19 /pmc/articles/PMC8161303/ /pubmed/34069724 http://dx.doi.org/10.3390/md19050281 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peng, Gao-Yang Kurtán, Tibor Mándi, Attila He, Jing Cao, Zheng-Yu Tang, Hua Mao, Shui-Chun Zhang, Wen Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title | Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title_full | Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title_fullStr | Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title_full_unstemmed | Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title_short | Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus |
title_sort | neuronal modulators from the coral-associated fungi aspergillus candidus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161303/ https://www.ncbi.nlm.nih.gov/pubmed/34069724 http://dx.doi.org/10.3390/md19050281 |
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