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Endophytes: the novel sources for plant terpenoid biosynthesis
Terpenoids are natural compounds predominantly present in plants. They have many pharmaceutical and/or nutritional functions, and have been widely applied in medical, food, and cosmetics industries. Recently, terpenoids have been used in the clinical treatment of COVID-19 due to the good antiviral a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161352/ https://www.ncbi.nlm.nih.gov/pubmed/34047817 http://dx.doi.org/10.1007/s00253-021-11350-7 |
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author | Chen, Yachao Hu, Bing Xing, Jianmin Li, Chun |
author_facet | Chen, Yachao Hu, Bing Xing, Jianmin Li, Chun |
author_sort | Chen, Yachao |
collection | PubMed |
description | Terpenoids are natural compounds predominantly present in plants. They have many pharmaceutical and/or nutritional functions, and have been widely applied in medical, food, and cosmetics industries. Recently, terpenoids have been used in the clinical treatment of COVID-19 due to the good antiviral activities. The increasing demand for terpenoids in international markets poses a serious threat to many plant species. For environmentally sustainable development, microbial cell factories have been utilized as the promising platform to produce terpenoids. Nevertheless, the bioproduction of most terpenoids cannot meet commercial requirements due to the low cost-benefit ratio until now. The biosynthetic potential of endophytes has gained attention in recent decades owing to the continual discovery of endophytes capable of synthesizing plant bioactive compounds. Accordingly, endophytes could be alternative sources of terpenoid-producing strains or terpenoid synthetic genes. In this review, we summarized the research progress describing the main and supporting roles of endophytes in terpenoid biosynthesis and biotransformation, and discussed the current problems and challenges which may prevent the further exploitation. This review will improve our understanding of endophyte resources for terpenoid production in industry in the future. GRAPHICAL ABSTRACT: [Figure: see text] Key points • The mechanisms employed by endophytes in terpenoid synthesis in vivo and in vitro. • Endophytes have the commercial potentials in terpenoid bioproduction and biotransformation. • Synthetic biology and multiomics will improve terpenoid bioproduction in engineered cell factories. |
format | Online Article Text |
id | pubmed-8161352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81613522021-05-28 Endophytes: the novel sources for plant terpenoid biosynthesis Chen, Yachao Hu, Bing Xing, Jianmin Li, Chun Appl Microbiol Biotechnol Mini-Review Terpenoids are natural compounds predominantly present in plants. They have many pharmaceutical and/or nutritional functions, and have been widely applied in medical, food, and cosmetics industries. Recently, terpenoids have been used in the clinical treatment of COVID-19 due to the good antiviral activities. The increasing demand for terpenoids in international markets poses a serious threat to many plant species. For environmentally sustainable development, microbial cell factories have been utilized as the promising platform to produce terpenoids. Nevertheless, the bioproduction of most terpenoids cannot meet commercial requirements due to the low cost-benefit ratio until now. The biosynthetic potential of endophytes has gained attention in recent decades owing to the continual discovery of endophytes capable of synthesizing plant bioactive compounds. Accordingly, endophytes could be alternative sources of terpenoid-producing strains or terpenoid synthetic genes. In this review, we summarized the research progress describing the main and supporting roles of endophytes in terpenoid biosynthesis and biotransformation, and discussed the current problems and challenges which may prevent the further exploitation. This review will improve our understanding of endophyte resources for terpenoid production in industry in the future. GRAPHICAL ABSTRACT: [Figure: see text] Key points • The mechanisms employed by endophytes in terpenoid synthesis in vivo and in vitro. • Endophytes have the commercial potentials in terpenoid bioproduction and biotransformation. • Synthetic biology and multiomics will improve terpenoid bioproduction in engineered cell factories. Springer Berlin Heidelberg 2021-05-28 2021 /pmc/articles/PMC8161352/ /pubmed/34047817 http://dx.doi.org/10.1007/s00253-021-11350-7 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Mini-Review Chen, Yachao Hu, Bing Xing, Jianmin Li, Chun Endophytes: the novel sources for plant terpenoid biosynthesis |
title | Endophytes: the novel sources for plant terpenoid biosynthesis |
title_full | Endophytes: the novel sources for plant terpenoid biosynthesis |
title_fullStr | Endophytes: the novel sources for plant terpenoid biosynthesis |
title_full_unstemmed | Endophytes: the novel sources for plant terpenoid biosynthesis |
title_short | Endophytes: the novel sources for plant terpenoid biosynthesis |
title_sort | endophytes: the novel sources for plant terpenoid biosynthesis |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161352/ https://www.ncbi.nlm.nih.gov/pubmed/34047817 http://dx.doi.org/10.1007/s00253-021-11350-7 |
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