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The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability

Background and Objectives: Endovascular thrombectomy (EVT is an emerging gold standard treatment for acute cerebral infarction and may allow functional improvement after subacute cerebral infarction. However, the long-term functional benefits of EVT in patients with moderate to severe disability rem...

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Autores principales: Yi, Ho-Jun, Lee, Dong-Hoon, Hong, Bo-Young, Song, Seung-Yoon, Yoo, Yeun-Jie, Yoon, Mi-Jeong, Sung, Jae-Hoon, Lim, Seong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161388/
https://www.ncbi.nlm.nih.gov/pubmed/34069555
http://dx.doi.org/10.3390/medicina57050509
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author Yi, Ho-Jun
Lee, Dong-Hoon
Hong, Bo-Young
Song, Seung-Yoon
Yoo, Yeun-Jie
Yoon, Mi-Jeong
Sung, Jae-Hoon
Lim, Seong-Hoon
author_facet Yi, Ho-Jun
Lee, Dong-Hoon
Hong, Bo-Young
Song, Seung-Yoon
Yoo, Yeun-Jie
Yoon, Mi-Jeong
Sung, Jae-Hoon
Lim, Seong-Hoon
author_sort Yi, Ho-Jun
collection PubMed
description Background and Objectives: Endovascular thrombectomy (EVT is an emerging gold standard treatment for acute cerebral infarction and may allow functional improvement after subacute cerebral infarction. However, the long-term functional benefits of EVT in patients with moderate to severe disability remain unclear. We investigated the effects of EVT on the activities of daily living (ADL), handicap, gait, and eating in patients with middle cerebral artery (MCA) occlusion who exhibited moderate to severe disability (score of 3–5 on the modified Rankin scale (mRS)) due to stroke, up to six months after onset. Materials and Methods: This retrospective longitudinal case–control study assessed 45 patients with MCA occlusion who exhibited moderate to severe disability (mRS score ≥ 3): 15 underwent EVT and 30 served as controls. Clinical assessments were conducted at two weeks (12–16 days), four weeks (26–30 days), and six months (180–210 days) after stroke onset. Functional assessments comprised the Korean version of the modified Barthel index (MBI), mRS, functional ambulation category (FAC), and dysphagia outcome severity scale (DOSS) to assess disability, handicap, gait, and eating. Results: The MBI, mRS, FAC, and DOSS scores all improved significantly (all p < 0.05) in the EVT group, compared to the controls. Conclusions: EVT has favorable effects on performing routine ADL, the handicap itself, walking, and eating. Therefore, EVT is recommended for patients with acute MCA occlusion, including those with severe disability at the initial assessment.
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spelling pubmed-81613882021-05-29 The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability Yi, Ho-Jun Lee, Dong-Hoon Hong, Bo-Young Song, Seung-Yoon Yoo, Yeun-Jie Yoon, Mi-Jeong Sung, Jae-Hoon Lim, Seong-Hoon Medicina (Kaunas) Article Background and Objectives: Endovascular thrombectomy (EVT is an emerging gold standard treatment for acute cerebral infarction and may allow functional improvement after subacute cerebral infarction. However, the long-term functional benefits of EVT in patients with moderate to severe disability remain unclear. We investigated the effects of EVT on the activities of daily living (ADL), handicap, gait, and eating in patients with middle cerebral artery (MCA) occlusion who exhibited moderate to severe disability (score of 3–5 on the modified Rankin scale (mRS)) due to stroke, up to six months after onset. Materials and Methods: This retrospective longitudinal case–control study assessed 45 patients with MCA occlusion who exhibited moderate to severe disability (mRS score ≥ 3): 15 underwent EVT and 30 served as controls. Clinical assessments were conducted at two weeks (12–16 days), four weeks (26–30 days), and six months (180–210 days) after stroke onset. Functional assessments comprised the Korean version of the modified Barthel index (MBI), mRS, functional ambulation category (FAC), and dysphagia outcome severity scale (DOSS) to assess disability, handicap, gait, and eating. Results: The MBI, mRS, FAC, and DOSS scores all improved significantly (all p < 0.05) in the EVT group, compared to the controls. Conclusions: EVT has favorable effects on performing routine ADL, the handicap itself, walking, and eating. Therefore, EVT is recommended for patients with acute MCA occlusion, including those with severe disability at the initial assessment. MDPI 2021-05-19 /pmc/articles/PMC8161388/ /pubmed/34069555 http://dx.doi.org/10.3390/medicina57050509 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yi, Ho-Jun
Lee, Dong-Hoon
Hong, Bo-Young
Song, Seung-Yoon
Yoo, Yeun-Jie
Yoon, Mi-Jeong
Sung, Jae-Hoon
Lim, Seong-Hoon
The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title_full The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title_fullStr The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title_full_unstemmed The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title_short The Long-Term Functional Effect of Thrombectomy on Patients with Middle Cerebral Artery Occlusion Who Exhibit Moderate to Severe Disability
title_sort long-term functional effect of thrombectomy on patients with middle cerebral artery occlusion who exhibit moderate to severe disability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161388/
https://www.ncbi.nlm.nih.gov/pubmed/34069555
http://dx.doi.org/10.3390/medicina57050509
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