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Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder
The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota–gut–brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161395/ https://www.ncbi.nlm.nih.gov/pubmed/34065187 http://dx.doi.org/10.3390/nu13051728 |
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author | Johnson, Dinyadarshini Thurairajasingam, Sivakumar Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han |
author_facet | Johnson, Dinyadarshini Thurairajasingam, Sivakumar Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han |
author_sort | Johnson, Dinyadarshini |
collection | PubMed |
description | The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota–gut–brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic–pituitary–adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants. |
format | Online Article Text |
id | pubmed-8161395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81613952021-05-29 Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder Johnson, Dinyadarshini Thurairajasingam, Sivakumar Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han Nutrients Review The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota–gut–brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic–pituitary–adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants. MDPI 2021-05-20 /pmc/articles/PMC8161395/ /pubmed/34065187 http://dx.doi.org/10.3390/nu13051728 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Johnson, Dinyadarshini Thurairajasingam, Sivakumar Letchumanan, Vengadesh Chan, Kok-Gan Lee, Learn-Han Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title | Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title_full | Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title_fullStr | Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title_full_unstemmed | Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title_short | Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder |
title_sort | exploring the role and potential of probiotics in the field of mental health: major depressive disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161395/ https://www.ncbi.nlm.nih.gov/pubmed/34065187 http://dx.doi.org/10.3390/nu13051728 |
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