Synthetic Organic “Aquachemistry” that Relies on Neither Cosolvents nor Surfactants

[Image: see text] There is a growing awareness of the underlying power of catalytic reactions in water that is not limited to innate sustainability alone. Some Type III reactions are catalytically accelerated without dissolution of reactants and are occasionally highly selective, as shown by comparison with the corresponding reactions run in organic solvents or under solvent-free conditions. Such catalysts are highly diversified, including hydrophilic, lipophilic, and even solid catalysts. In this Outlook, we highlight the impressive characteristics of illustrative catalysis that is exerted despite the immiscibility of the substrates and reveal the intrinsic benefits of these enigmatic reactions for synthetic organic chemistry, albeit with many details remaining unclear. We hope that this brief introduction to the expanding field of synthetic organic “aquachemistry” will inspire organic chemists to use the platform to invent new transformations.