Comprehensive Structure–Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C–H Functionalization

[Image: see text] The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of acti...

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Detalles Bibliográficos
Autores principales: Alwaseem, Hanan, Giovani, Simone, Crotti, Michele, Welle, Kevin, Jordan, Craig T., Ghaemmaghami, Sina, Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161485/
https://www.ncbi.nlm.nih.gov/pubmed/34079900
http://dx.doi.org/10.1021/acscentsci.0c01624

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