Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

[Image: see text] Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated the transcriptional coactivator, E...

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Detalles Bibliográficos
Autores principales: Garnar-Wortzel, Leopold, Bishop, Timothy R., Kitamura, Seiya, Milosevich, Natalia, Asiaban, Joshua N., Zhang, Xiaoyu, Zheng, Qinheng, Chen, Emily, Ramos, Anissa R., Ackerman, Christopher J., Hampton, Eric N., Chatterjee, Arnab K., Young, Travis S., Hull, Mitchell V., Sharpless, K. Barry, Cravatt, Benjamin F., Wolan, Dennis W., Erb, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161486/
https://www.ncbi.nlm.nih.gov/pubmed/34079898
http://dx.doi.org/10.1021/acscentsci.0c01550

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