Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

[Image: see text] The use of computational tools to identify biological targets of natural products with anticancer properties and unknown modes of action is gaining momentum. We employed self-organizing maps to deconvolute the phenotypic effects of piperlongumine (PL) and establish a link to modula...

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Detalles Bibliográficos
Autores principales: Conde, João, Pumroy, Ruth A., Baker, Charlotte, Rodrigues, Tiago, Guerreiro, Ana, Sousa, Bárbara B., Marques, Marta C., de Almeida, Bernardo P., Lee, Sohyon, Leites, Elvira P., Picard, Daniel, Samanta, Amrita, Vaz, Sandra H., Sieglitz, Florian, Langini, Maike, Remke, Marc, Roque, Rafael, Weiss, Tobias, Weller, Michael, Liu, Yuhang, Han, Seungil, Corzana, Francisco, Morais, Vanessa A., Faria, Cláudia C., Carvalho, Tânia, Filippakopoulos, Panagis, Snijder, Berend, Barbosa-Morais, Nuno L., Moiseenkova-Bell, Vera Y., Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161495/
https://www.ncbi.nlm.nih.gov/pubmed/34079902
http://dx.doi.org/10.1021/acscentsci.1c00070

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