Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum–hippocampus cholinergic pathway

Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in t...

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Detalles Bibliográficos
Autores principales: Wu, Dongqin, Gao, Di, Yu, Haitao, Pi, Guilin, Xiong, Rui, Lei, Huiyang, Wang, Xin, Liu, Enjie, Ye, Jinwang, Yu, Huilin, Gao, Yang, He, Ting, Jiang, Tao, Sun, Fei, Su, Jingfen, Song, Guoda, Peng, Wenju, Yang, Ying, Wang, Jian‐Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161512/
https://www.ncbi.nlm.nih.gov/pubmed/34185417
http://dx.doi.org/10.1002/ctm2.428

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