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Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

BACKGROUND: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to th...

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Autores principales: Begum-Ali, Jannath, Kolesnik-Taylor, Anna, Quiroz, Isabel, Mason, Luke, Garg, Shruti, Green, Jonathan, Johnson, Mark H., Jones, Emily J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161667/
https://www.ncbi.nlm.nih.gov/pubmed/34049498
http://dx.doi.org/10.1186/s11689-021-09364-3
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author Begum-Ali, Jannath
Kolesnik-Taylor, Anna
Quiroz, Isabel
Mason, Luke
Garg, Shruti
Green, Jonathan
Johnson, Mark H.
Jones, Emily J. H.
author_facet Begum-Ali, Jannath
Kolesnik-Taylor, Anna
Quiroz, Isabel
Mason, Luke
Garg, Shruti
Green, Jonathan
Johnson, Mark H.
Jones, Emily J. H.
author_sort Begum-Ali, Jannath
collection PubMed
description BACKGROUND: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. METHODS: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. RESULTS: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. CONCLUSIONS: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-021-09364-3.
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spelling pubmed-81616672021-06-01 Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I Begum-Ali, Jannath Kolesnik-Taylor, Anna Quiroz, Isabel Mason, Luke Garg, Shruti Green, Jonathan Johnson, Mark H. Jones, Emily J. H. J Neurodev Disord Research BACKGROUND: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. METHODS: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. RESULTS: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. CONCLUSIONS: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-021-09364-3. BioMed Central 2021-05-28 /pmc/articles/PMC8161667/ /pubmed/34049498 http://dx.doi.org/10.1186/s11689-021-09364-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Begum-Ali, Jannath
Kolesnik-Taylor, Anna
Quiroz, Isabel
Mason, Luke
Garg, Shruti
Green, Jonathan
Johnson, Mark H.
Jones, Emily J. H.
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title_full Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title_fullStr Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title_full_unstemmed Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title_short Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I
title_sort early differences in auditory processing relate to autism spectrum disorder traits in infants with neurofibromatosis type i
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161667/
https://www.ncbi.nlm.nih.gov/pubmed/34049498
http://dx.doi.org/10.1186/s11689-021-09364-3
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