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Structural impact of GTP binding on downstream KRAS signaling

Oncogenic RAS proteins, involved in ∼30% of human tumors, are molecular switches of various signal transduction pathways. Here we apply a new protocol for the NMR study of KRAS in its (inactive) GDP- and (activated) GTP-bound form, allowing a comprehensive analysis of the backbone dynamics of its WT...

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Detalles Bibliográficos
Autores principales:	Menyhárd, Dóra K., Pálfy, Gyula, Orgován, Zoltán, Vida, István, Keserű, György M., Perczel, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161693/ https://www.ncbi.nlm.nih.gov/pubmed/34094198 http://dx.doi.org/10.1039/d0sc03441j

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